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. 1979 May;17(5):747-52.
doi: 10.1016/s0090-6980(79)80046-5.

The major product of PGG2 metabolism by aortic microsomes is 6, 15-dioxo-PGF1 alpha

J A Salmon, D R Smith, F Cottee

The major product of PGG2 metabolism by aortic microsomes is 6, 15-dioxo-PGF1 alpha

J A Salmon et al. Prostaglandins. 1979 May.

Abstract

Incubations of PGG2 with aortic microsomes yielded two products which were not formed in boiled enzyme control, one of which was 6-oxo-PGF1 alpha. The major metabolite was identified by gas-liquid chromatography-mass spectrometry as 6,15-dioxo-PGF1 alpha. Thus, unlike PGH2, PGG2 is probably converted to 15-hydroperoxy PGI2 which subsequently decomposes to 6, 15-dioxo-PGF1 alpha.

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