doi: 10.1016/s0090-6980(79)80048-9.
Beneficial actions of prostacyclin in traumatic shock
- PMID: 386429
- DOI: 10.1016/s0090-6980(79)80048-9
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Beneficial actions of prostacyclin in traumatic shock
Prostaglandins.
1979 May.
Abstract
Prostacyclin (PGI2) infused at a rate of 350 ng/kg/min significantly increased survival time in rats subjected to Noble-Collip drug trauma from 2.7 +/- 0.3 to 4.6 +/- 0.2 h (p less than 0.01) compared with traumatized rats given only the vehicle (Tris buffer). Moreover, PGI2 treated rats exhibited significantly lower circulating cathepsin D and myocardial depressant factor (MDF) activities, indicative of lower lysosomal disruption and lower toxic factor formation. PGI2 induced vasodilation in rats as well as these other protective effects.
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