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. 1979 May;17(5):761-7.
doi: 10.1016/s0090-6980(79)80048-9.

Beneficial actions of prostacyclin in traumatic shock

A M Lefer, S L Sollott, M J Galvin

Beneficial actions of prostacyclin in traumatic shock

A M Lefer et al. Prostaglandins. 1979 May.

Abstract

Prostacyclin (PGI2) infused at a rate of 350 ng/kg/min significantly increased survival time in rats subjected to Noble-Collip drug trauma from 2.7 +/- 0.3 to 4.6 +/- 0.2 h (p less than 0.01) compared with traumatized rats given only the vehicle (Tris buffer). Moreover, PGI2 treated rats exhibited significantly lower circulating cathepsin D and myocardial depressant factor (MDF) activities, indicative of lower lysosomal disruption and lower toxic factor formation. PGI2 induced vasodilation in rats as well as these other protective effects.

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