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Meta-Analysis
. 2024 Apr 20;23(1):115.
doi: 10.1186/s12944-024-02095-z.

Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride-glucose index with arterial stiffness risk

Wenkai Zhang  1 , Weifeng Huo  1 , Huifang Hu  1 , Tianze Li  1 , Lijun Yuan  1 , Jinli Zhang  1 , Yifei Feng  1 , Yuying Wu  1 , Xueru Fu  1 , Yamin Ke  1 , Mengmeng Wang  1 , Longkang Wang  1 , Yaobing Chen  1 , Yajuan Gao  1 , Xi Li  1 , Liang Sun  2 , Jinyuan Pang  3 , Zeqiang Zheng  3 , Fulan Hu  4   5 , Ming Zhang  4   5 , Yu Liu  6 , Dongsheng Hu  7   8 , Yang Zhao  9   10
Affiliations
Meta-Analysis

Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride-glucose index with arterial stiffness risk

Wenkai Zhang et al. Lipids Health Dis. .

Abstract

Background: The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and triglyceride-glucose (TyG) index are novel indexes for insulin resistance (IR). We aimed to evaluate associations of TG/HDL-C and TyG with arterial stiffness risk.

Methods: We enrolled 1979 participants from the Rural Chinese Cohort Study, examining arterial stiffness by brachial-ankle pulse wave velocity (baPWV). Logistic and linear regression models were employed to calculate effect estimates. For meta-analysis, we searched relevant articles from PubMed, Embase and Web of Science up to August 26, 2023. The fixed-effects or random-effects models were used to calculate the pooled estimates. We evaluated dose-response associations using restricted cubic splines.

Results: For cross-sectional studies, the adjusted ORs (95%CIs) for arterial stiffness were 1.12 (1.01-1.23) and 1.78 (1.38-2.30) for per 1 unit increment in TG/HDL-C and TyG. In the meta-analysis, the pooled ORs (95% CIs) were 1.26 (1.14-1.39) and 1.57 (1.36-1.82) for per 1 unit increment of TG/HDL-C and TyG. Additionally, both TG/HDL-C and TyG were positively related to PWV, with β of 0.09 (95% CI 0.04-0.14) and 0.57 (95% CI 0.35-0.78) m/s. We also found linear associations of TG/HDL-C and TyG with arterial stiffness risk.

Conclusions: High TG/HDL-C and TyG were related to increased arterial stiffness risk, indicating TG/HDL-C and TyG may be convincing predictors of arterial stiffness.

Keywords: Arterial stiffness; Meta-analysis; Pulse wave velocity; Triglyceride to high-density lipoprotein cholesterol ratio; Triglyceride-glucose index.

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Conflict of interest statement

The authors declare no competing interests.

The authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Subgroup analysis of associations between TG/HDL-C and TyG index (per 1 unit increment) and arterial stiffness Data are shown as OR (95% CI). Note: Adjusted for age, gender, marital status, education, smoking, alcohol drinking, physical activity, body mass index, waist circumference, systolic and diastolic blood pressure, total cholesterol, a for TG/HDL-C, b for TyG index
Fig. 2
Fig. 2
Forest plot of study-specific risks for arterial stiffness with highest versus lowest TG/HDL-C and TyG index
Fig. 3
Fig. 3
Dose?response association of TG/HDL-C (A) and TyG index (B) with the risk of arterial stiffness.
Fig. 4
Fig. 4
Forest plot of study-specific risks between TG/HDL-C and TyG index (per 1 unit increment) and arterial stiffness.
See this image and copyright information in PMC

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References

    1. Global burden Of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of Disease Study 2019. Lancet. 2020;396:1204–22. - PMC - PubMed
    1. Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton AZ, Benjamin EJ, Benziger CP, et al. Global Burden of Cardiovascular diseases and Risk factors, 1990–2019: Update from the GBD 2019 study. J Am Coll Cardiol. 2020;76:2982–3021. - PMC - PubMed
    1. Chirinos JA, Segers P, Hughes T, Townsend R. Large-artery stiffness in Health and Disease: JACC State-of-the-art review. J Am Coll Cardiol. 2019;74:1237–63. - PMC - PubMed
    1. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588–605. - PubMed
    1. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010;55:1318–27. - PubMed

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