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Meta-Analysis
. 2024 Apr 20;23(1):115.
doi: 10.1186/s12944-024-02095-z.

Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride-glucose index with arterial stiffness risk

Wenkai Zhang  1 , Weifeng Huo  1 , Huifang Hu  1 , Tianze Li  1 , Lijun Yuan  1 , Jinli Zhang  1 , Yifei Feng  1 , Yuying Wu  1 , Xueru Fu  1 , Yamin Ke  1 , Mengmeng Wang  1 , Longkang Wang  1 , Yaobing Chen  1 , Yajuan Gao  1 , Xi Li  1 , Liang Sun  2 , Jinyuan Pang  3 , Zeqiang Zheng  3 , Fulan Hu  4   5 , Ming Zhang  4   5 , Yu Liu  6 , Dongsheng Hu  7   8 , Yang Zhao  9   10
Affiliations
Meta-Analysis

Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride-glucose index with arterial stiffness risk

Wenkai Zhang et al. Lipids Health Dis. .

Abstract

Background: The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and triglyceride-glucose (TyG) index are novel indexes for insulin resistance (IR). We aimed to evaluate associations of TG/HDL-C and TyG with arterial stiffness risk.

Methods: We enrolled 1979 participants from the Rural Chinese Cohort Study, examining arterial stiffness by brachial-ankle pulse wave velocity (baPWV). Logistic and linear regression models were employed to calculate effect estimates. For meta-analysis, we searched relevant articles from PubMed, Embase and Web of Science up to August 26, 2023. The fixed-effects or random-effects models were used to calculate the pooled estimates. We evaluated dose-response associations using restricted cubic splines.

Results: For cross-sectional studies, the adjusted ORs (95%CIs) for arterial stiffness were 1.12 (1.01-1.23) and 1.78 (1.38-2.30) for per 1 unit increment in TG/HDL-C and TyG. In the meta-analysis, the pooled ORs (95% CIs) were 1.26 (1.14-1.39) and 1.57 (1.36-1.82) for per 1 unit increment of TG/HDL-C and TyG. Additionally, both TG/HDL-C and TyG were positively related to PWV, with β of 0.09 (95% CI 0.04-0.14) and 0.57 (95% CI 0.35-0.78) m/s. We also found linear associations of TG/HDL-C and TyG with arterial stiffness risk.

Conclusions: High TG/HDL-C and TyG were related to increased arterial stiffness risk, indicating TG/HDL-C and TyG may be convincing predictors of arterial stiffness.

Keywords: Arterial stiffness; Meta-analysis; Pulse wave velocity; Triglyceride to high-density lipoprotein cholesterol ratio; Triglyceride-glucose index.

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Conflict of interest statement

The authors declare no competing interests.

The authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Subgroup analysis of associations between TG/HDL-C and TyG index (per 1 unit increment) and arterial stiffness Data are shown as OR (95% CI). Note: Adjusted for age, gender, marital status, education, smoking, alcohol drinking, physical activity, body mass index, waist circumference, systolic and diastolic blood pressure, total cholesterol, a for TG/HDL-C, b for TyG index
Fig. 2
Fig. 2
Forest plot of study-specific risks for arterial stiffness with highest versus lowest TG/HDL-C and TyG index
Fig. 3
Fig. 3
Dose?response association of TG/HDL-C (A) and TyG index (B) with the risk of arterial stiffness.
Fig. 4
Fig. 4
Forest plot of study-specific risks between TG/HDL-C and TyG index (per 1 unit increment) and arterial stiffness.
See this image and copyright information in PMC

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