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. 2024 Sep;28(9):925-931.
doi: 10.1007/s10157-024-02498-3. Epub 2024 Apr 20.

Circulating galectin-3 level association with cardiovascular risk factors during peritoneal dialysis

Xuerui Yang  1 , Jun Yang  1 , Youjia Zeng  1 , Ling Peng  1 , Xingzheng Liu  1 , Jinying Mo  1 , Taifen Wang  1 , Yutong Yao  1 , Yihou Zheng  1 , Gaofeng Song  2
Affiliations

Circulating galectin-3 level association with cardiovascular risk factors during peritoneal dialysis

Xuerui Yang et al. Clin Exp Nephrol. 2024 Sep.

Abstract

Objective: Cardiovascular disease (CVD) represents the primary cause of mortality in patients afflicted with end-stage renal disease and undergoing peritoneal dialysis (PD) treatment. Galectin-3 (Gal-3), a molecule known to exhibit a correlation with CVD mortality garners considerable interest. The objective of this study was to explore the potential association between serum Gal-3 levels and other CVD risk factors among PD patients.

Methods: In this cross-sectional study, a total of 114 PD patients with a minimum of 3 months of PD treatment were enrolled. Serum Gal-3 levels were quantified using an enzyme-linked immunosorbent assay. The data of patients with Gal-3 levels higher and lower than 26.744 pg/ml were compared using Mann-Whitney U tests or t tests. Pearson's correlation or Spearman's correlation analysis and multivariate regression were used to assess the associations between the known risk factors for CVD and Gal-3.

Results: In comparison to the inter-group baseline data, the low Gal-3 group exhibited a higher glomerular filtration rate (GFR). Gal-3 levels correlate positively with PD duration, B-type natriuretic peptide (BNP), growth differentiation factor 15 (GDF-15), interventricular septal thickness in diastolic (IVST), and left ventricular mass index (LVMI). Conversely, Gal-3 exhibited a negative correlation with albumin levels. Multivariate linear regression analysis demonstrated a positive correlation between Gal-3 levels and BNP, GDF-15, PD duration, IVST and LVMI. Gal-3 levels were negatively correlated with albumin levels.

Conclusions: Gal-3 was strongly associated with BNP, GDF-15, IVST and LVMI in patients undergoing PD treatment. Prospective studies should be carried out to determine whether Gal-3 can be a promising biomarker in predicting increased risk of adverse cardiovascular events in PD patients.

Keywords: Cardiovascular disease; Chronic kidney disease; Galectin-3; Peritoneal dialysis.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Fig. 1
Fig. 1
Flowchart of the study process. PD peritoneal dialysis, Gal-3 galectin-3
See this image and copyright information in PMC

References

    1. Ortiz A, Covic A, Fliser D, Fouque D, Goldsmith D, Kanbay M, Mallamaci F, Massy ZA, Rossignol P, Vanholder R, Wiecek A, Zoccali C, London GM. Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. Lancet. 2014;383(9931):1831–43. 10.1016/S0140-6736(14)60384-6 - DOI - PubMed
    1. Bello AK, Okpechi IG, Osman MA, Cho Y, Cullis B, Htay H, Jha V, Makusidi MA, McCulloch M, Shah N, Wainstein M, Johnson DW. Epidemiology of peritoneal dialysis outcomes. Nat Rev Nephrol. 2022;18(12):779–93. 10.1038/s41581-022-00623-7 - DOI - PMC - PubMed
    1. Rossignol P, Pitt B, Thompson A, Zannad F. Roadmap for cardiovascular prevention trials in chronic kidney disease. Lancet. 2016;388(10055):1964–6. 10.1016/S0140-6736(16)31331-9 - DOI - PubMed
    1. Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, McCullough PA, Kasiske BL, Kelepouris E, Klag MJ, Parfrey P, Pfeffer M, Raij L, Spinosa DJ, Wilson PW, American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Hypertension. 2003;42(5):1050–65. 10.1161/01.HYP.0000102971.85504.7c - DOI - PubMed
    1. Hara A, Niwa M, Kanayama T, Noguchi K, Niwa A, Matsuo M, Kuroda T, Hatano Y, Okada H, Tomita H. Galectin-3: a potential prognostic and diagnostic marker for heart disease and detection of early stage pathology. Biomolecules. 2020;10(9):1277. 10.3390/biom10091277 - DOI - PMC - PubMed

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