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Review
. 2024 Mar-Apr;29(2):e13071.
doi: 10.1111/hel.13071.

The role of microbiota in gastric cancer: A comprehensive review

Changzhen Lei  1 , Yitian Xu  1 , Shaopeng Zhang  1 , Chen Huang  1 , Jing Qin  1
Affiliations
Review

The role of microbiota in gastric cancer: A comprehensive review

Changzhen Lei et al. Helicobacter. 2024 Mar-Apr.

Abstract

Background: Gastric cancer (GC) continues to pose a significant global threat in terms of cancer-related fatalities. Despite notable advancements in medical research and therapies, further investigation is warranted to elucidate its underlying etiology and risk factors. Recent times have witnessed an escalated emphasis on comprehending the role of the microbiota in cancer development.

Methods: This review briefly delves into recent developments in microbiome-related research pertaining to gastric cancer.

Results: According to studies, the microbiota can influence GC growth by inciting inflammation, disrupting immunological processes, and generating harmful microbial metabolites. Furthermore, there is ongoing research into how the microbiome can impact a patient's response to chemotherapy and immunotherapy.

Conclusion: The utilization of the microbiome for detecting, preventing, and managing stomach cancer remains an active area of exploration.

Keywords: biomarkers; gastric cancer; mechanisms; metabolite; microbiota; therapy.

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References

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