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. 2024:42:103607.
doi: 10.1016/j.nicl.2024.103607. Epub 2024 Apr 18.

The connection of motor improvement after deep brain stimulation in Parkinson's disease and microstructural integrity of the substantia nigra and subthalamic nucleus

Marco G Hermann  1 , Nils Schröter  2 , Alexander Rau  3 , Marco Reisert  4 , Nadja Jarc  1 , Michel Rijntjes  2 , Jonas A Hosp  2 , Peter C Reinacher  5 , Wolfgang H Jost  6 , Horst Urbach  7 , Cornelius Weiller  2 , Volker A Coenen  8 , Bastian E A Sajonz  9
Affiliations

The connection of motor improvement after deep brain stimulation in Parkinson's disease and microstructural integrity of the substantia nigra and subthalamic nucleus

Marco G Hermann et al. Neuroimage Clin. 2024.

Abstract

Background: Nigrostriatal microstructural integrity has been suggested as a biomarker for levodopa response in Parkinson's disease (PD), which is a strong predictor for motor response to deep brain stimulation (DBS) of the subthalamic nucleus (STN). This study aimed to explore the impact of microstructural integrity of the substantia nigra (SN), STN, and putamen on motor response to STN-DBS using diffusion microstructure imaging.

Methods: Data was collected from 23 PD patients (mean age 63 ± 7, 6 females) who underwent STN-DBS, had preoperative 3 T diffusion magnetic resonance imaging including multishell diffusion-weighted MRI with b-values of 1000 and 2000 s/mm2 and records of motor improvement available.

Results: The association between a poorer DBS-response and increased free interstitial fluid showed notable effect sizes (rho > |0.4|) in SN and STN, but not in putamen. However, this did not reach significance after Bonferroni correction and controlling for sex and age.

Conclusion: Microstructural integrity of SN and STN are potential biomarkers for the prediction of therapy efficacy following STN-DBS, but further studies are required to confirm these associations.

Keywords: Deep Brain Stimulation; Diffusion Microstructure Imaging (DMI); Microstructural integrity; Parkinson’s disease; Therapy response.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Association of microstructural free fluid (V-CSF) in Putamen, Substantia nigra and subthalamic nucleus with motor improvement by STN-DBS controlling for age and sex. Each dot represents a single patient. Dashed lines are used to point out the bigger effect sizes of the associations in the two upper graphs, which however do not reach the α-level of 0.016.
See this image and copyright information in PMC

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