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Case Reports
. 2024 May;24(3):100203.
doi: 10.1016/j.clinme.2024.100203. Epub 2024 Apr 19.

Extramedullary haematopoiesis in a patient with myelofibrosis

Elaina Pasangha  1 , Johanna Wall  2 , Anita Arasaretnam  2
Affiliations
Case Reports

Extramedullary haematopoiesis in a patient with myelofibrosis

Elaina Pasangha et al. Clin Med (Lond). 2024 May.

Abstract

Megakaryocytes are large multilobulated precursor cells which usually reside within the bone marrow and give rise to platelets. There have been rare occurrences where they have been found in peripheral blood and extramedullary tissues in conditions where the underlying mechanisms of the bone marrow have been affected. This case report discusses an unusual presentation of a man with myelofibrosis who was found to have megakaryocytes in his ascitic fluid. We have highlighted the images showing utility of combination of traditional staining methods and immunohistochemistry in combating this diagnostic dilemma.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no conflict of interest

Figures

Fig 1
Fig. 1
MGG stained cytospin preparation x10 magnification (x2 magnification inset).
Fig 2
Fig. 2
PAP stained cytospin preparation x10 magnification (x2 magnification inset).
Fig 3
Fig. 3
CD61 Immunohistochemistry x4 magnification.
See this image and copyright information in PMC

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