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. 2024 Apr;15(2):125-128.
doi: 10.14740/cr1624. Epub 2024 Apr 15.

Prevalence of Aortic Root Pathologies in Platypnea-Orthodeoxia Syndrome Secondary to Intra-Cardiac Shunts

Omer Farooq  1 , Usman Ghani  2 , Harvey Friedman  3 , Muhammad Sikander Akbar  4 , Hammad Saudye  4 , Sundus Alam  5 , Muhammad Junaid Khan  5 , Sumeet Mutti  1
Affiliations

Prevalence of Aortic Root Pathologies in Platypnea-Orthodeoxia Syndrome Secondary to Intra-Cardiac Shunts

Omer Farooq et al. Cardiol Res. 2024 Apr.

Abstract

Background: Atrial septal defects can allow right to left shunting of venous blood which presents clinically as platypnea-orthodeoxia syndrome. It is believed that concomitant presence of aortic root pathologies increases the likelihood of shunting.

Methods: The study included a review of 510 articles listed in PubMed of patients with platypnea-orthodeoxia syndrome. Case reports of patients with extra-cardiac etiologies of platypnea-orthodeoxia were excluded.

Results: We reviewed 191 case reports, and 98 cases (51.3%) had evidence of concomitant aortic root pathology. Furthermore, of the remaining 93 case reports, 69 ones excluded any mention of the nature of the aortic root altogether, further suggesting that this is an underreported number.

Conclusions: There is a high prevalence of aortic root pathologies in patients with platypnea-orthodeoxia syndrome secondary to intra-cardiac shunts. In patients with unexplained hypoxemia and incidental finding of aortic root pathology, it may be worthwhile to obtain postural oxygen saturation measurements to exclude intra-cardiac shunts as the potential cause.

Keywords: Aortic aneurysm; Aortic elongation; Aortic root pathology; Atrial septal defect; Orthodeoxia; Patent foramen ovale; Platypnea; Platypnea-orthodeoxia syndrome.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Illustration of the literature review process. POS: platypnea-orthodeoxia syndrome.
See this image and copyright information in PMC

References

    1. Tobis JM, Abudayyeh I. Platypnea-Orthodeoxia syndrome: an overlooked cause of hypoxemia. JACC Cardiovasc Interv. 2016;9(18):1939–1940. doi: 10.1016/j.jcin.2016.08.002. - DOI - PubMed
    1. Rodrigues P, Palma P, Sousa-Pereira L. Platypnea-Orthodeoxia syndrome in review: defining a new disease? Cardiology. 2012;123(1):15–23. doi: 10.1159/000339872. - DOI - PubMed
    1. Chen GP, Goldberg SL, Gill EA Jr. Patent foramen ovale and the platypnea-orthodeoxia syndrome. Cardiol Clin. 2005;23(1):85–89. doi: 10.1016/j.ccl.2004.10.003. - DOI - PubMed
    1. Agrawal A, Palkar A, Talwar A. The multiple dimensions of Platypnea-Orthodeoxia syndrome: A review. Respir Med. 2017;129:31–38. doi: 10.1016/j.rmed.2017.05.016. - DOI - PubMed
    1. Eicher JC, Bonniaud P, Baudouin N, Petit A, Bertaux G, Donal E, Piechaud JF. et al. Hypoxaemia associated with an enlarged aortic root: a new syndrome? Heart. 2005;91(8):1030–1035. doi: 10.1136/hrt.2003.027839. - DOI - PMC - PubMed

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