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. 2024 Apr 5:18:100668.
doi: 10.1016/j.ajpc.2024.100668. eCollection 2024 Jun.

Association of change in cardiovascular health based on life's essential 8 with incident cardiovascular disease

Chao Song  1 , Xunjie Cheng  2 , Yongping Bai  2   3
Affiliations

Association of change in cardiovascular health based on life's essential 8 with incident cardiovascular disease

Chao Song et al. Am J Prev Cardiol. .

Abstract

Objective: To evaluate whether and to what extent changes in cardiovascular health (CVH) based on life's essential 8 (LE8) are associated with incident cardiovascular disease (CVD).

Methods: A total of 7,194 participants were derived from UK Biobank. CVH was evaluated using a modified version of LE8. Participants were classified into three groups according to their LE8 score: high CVH (LE8 score≥80), moderate CVH (50≤LE8 score<80), and low CVH (LE8 score<50). Changes in CVH between 2006/2010 and 2012/2013 were analyzed.

Results: During a median of 10.3 years of follow-up, CVD was observed in 597 participants. Compared to the consistent moderate group, the moderate to low group was associated with about 128 % increased risk of CVD (Hazard ratio [HR]: 2.28; 95 % confidence interval [CI]: 1.61, 3.23), and the relevant HR (95 % CI) was 2.19 (1.46, 3.29) for the consistent low group; no statistically significant results were observed in the other groups. Moreover, no statistically significant exposure-response association between absolute change in LE8 score and incident CVD was documented (Poverall=0.15).

Conclusion: Change in CVH based on LE8 was associated with the risk of CVD; however, the relationship varied widely in different CVH change patterns.

Keywords: Cardiovascular health; Change; Life's essential 8; Preventive cardiology; Risk factors.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

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Central Illustration
Fig 1
Fig. 1
Association between CVH change patterns and CVD incidence.
Fig 2
Fig. 2
Exposure-response association between change of CVH score and CVD incidence.
See this image and copyright information in PMC

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