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. 2024 Apr 6;27(5):109680.
doi: 10.1016/j.isci.2024.109680. eCollection 2024 May 17.

Endometriosis and endometrial cancer: A propensity score-adjusted real-world data study

Alberto Farolfi  1 , Nicola Gentili  2 , Sara Testoni  3 , Francesca Rusconi  4 , Ilaria Massa  2 , Valentina Danesi  2 , Amelia Altavilla  1 , Maria C Cursano  1 , Giorgia Gurioli  5 , Salvatore L Burgio  1 , Gema Hernandez Ibarburu  5 , Ugo De Giorgi  1
Affiliations

Endometriosis and endometrial cancer: A propensity score-adjusted real-world data study

Alberto Farolfi et al. iScience. .

Abstract

Endometriosis is a benign condition characterized by the presence of ectopic endometrial tissue. Our study investigated the effect of endometriosis on the risk of endometrial cancer (EC) and the prognosis of endometriosis-associated EC. In our study, 197,196 patients with endometriosis and without a previous diagnosis of EC were compared with 6,455,556 females encountering health services for examinations, with body mass index (BMI) data, and without endometriosis or EC. A propensity score generated 197,141 matched pairs. In the endometriosis cohort, 875 cases of EC were seen, whereas 558 were in the control group: the hazard ratio (HR) was 1.56 (95% CI 1.40-1.73, p < 0.001). Women with endometriosis were more likely to develop invasive endometrioid (p = 0.005) and clear cell (p < 0.001) EC. There was no difference in overall survival between endometriosis-associated EC and EC without endometriosis. Our epidemiological findings were consistent with the evidence of an association between endometriosis and EC.

Keywords: Cancer; Female reproductive endocrinology; Health sciences; Public health.

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Conflict of interest statement

A.F.: Financial interests, personal, advisory board: AstraZeneca, GSK, Janssen; financial interests, personal, invited speaker: GSK, Clovis Oncology, AstraZeneca. U.F.F. De Giorgi: Financial interests, personal, advisory board: Pfizer, BMS, MSD, PharmaMar, Astellas, Bayer, Ipsen, Novartis, EISAI, Janssen; financial interests, personal, invited speaker: Roche, BMS, Clovis Oncology, AstraZeneca; financial interests, institutional, research grant: AstraZeneca, Sanofi, Roche. F.R. and G.H.I.: Financial interests, personal, full or part-time employment: TriNexT, Inc.

Figures

None
Graphical abstract
Figure 1
Figure 1
Patient flow chart Flow chart for the identification of cohorts analyzed.
Figure 2
Figure 2
Overall survival Estimation of overall survival for patients with endometriosis-associated endometrial cancer (red line) and patients with endometrial cancer without endometriosis (blue line).
See this image and copyright information in PMC

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