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. 2024 Aug 1;20(8):1349-1355.
doi: 10.5664/jcsm.11168.

Exploring sleep characteristics in Chinese patients with narcolepsy: insights from the nocturnal sleep onset rapid eye movement period (nSOREMP)

Shufei Zeng  1   2 , Fei Feng  3 , Weimin Li  1   2 , Yan Xu  1   2 , Rui Zhao  4 , Shengpeng Liang  1   2 , Yihong Cheng  1   2 , Ruichen Fang  1   2 , Hailing Jia  5 , Yang Wang  6 , Dongsheng Lv  4 , Bin Zhang  1   2
Affiliations

Exploring sleep characteristics in Chinese patients with narcolepsy: insights from the nocturnal sleep onset rapid eye movement period (nSOREMP)

Shufei Zeng et al. J Clin Sleep Med. .

Abstract

Study objectives: This study aimed to investigate the unique characteristics and clinical significance of the nocturnal sleep onset rapid eye movement period (nSOREMP) in the Chinese population with narcolepsy, enhancing our understanding and management of the disorder globally.

Methods: This retrospective analysis investigated narcolepsy in Chinese patients from six hospitals, using the International Classification of Sleep Disorders. A parallel retrospective analysis of the Chinese Clinical Sleep Database focused on polysomnography records was conducted to evaluate nSOREMP prevalence in other sleep disorders.

Results: The study found a 2.51% nSOREMP prevalence in other sleep disorders in the Chinese Clinical Sleep Database. Significant differences in age, N2 and rapid eye movement percentages, rapid eye movement latency, and various indexes were noted among patients with narcolepsy with or without nSOREMP and other sleep disorders with nSOREMP in the Chinese Clinical Sleep Database. nSOREMP prevalence in narcolepsy type 1 was 33.33% and in narcolepsy type 2 was 28.30%. Noteworthy disparities in narcolepsy type 1 included N2 percentages, rapid eye movement latency, and SOREMPs on Multiple Sleep Latency Test. In narcolepsy type 2, differences were significant for age, sleep latency, N2 and rapid eye movement latencies, arousal index, mean sleep latency on the Multiple Sleep Latency Test, and Multiple Sleep Latency Test SOREMPs.

Conclusions: This study highlights the distinct characteristics of nSOREMP in the Chinese population. Patients exhibiting symptoms suggestive of the onset of narcolepsy are advised to undergo a Multiple Sleep Latency Test, irrespective of the occurrence of SOREMP during nocturnal polysomnography.

Citation: Zeng S, Feng F, Li W, et al. Exploring sleep characteristics in Chinese patients with narcolepsy: insights from the nocturnal sleep onset rapid eye movement period (nSOREMP). J Clin Sleep Med. 2024;20(8):1349-1355.

Keywords: Multiple Sleep Latency Test; narcolepsy; nocturnal sleep onset rapid eye movement period; polysomnography; sleep.

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Conflict of interest statement

All of the authors have seen and approved the manuscript. Work for this study was performed at the Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. This work was supported by the National Key R&D Program of China (grant number 2021YFC2501500), National Natural Science Foundation of China (grant number 82271525), Nanfang Hospital Clinical Research Project of Southern Medical University (grant number 2021CR009), and National Natural Science Foundation of China (grant number 82071488). The authors report no conflicts of interest.

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