[Senile plaques, neuro-fibrillar degeneration and other associated cerebral lesions (morphology and pathogenetic theory]

Abstract

A brief review about present knowledge on morphology of brain degenerative alterations in the elderly, their topography, their correlations and the various pathogenic theories. The particular pathoclisis of some areas is reported, i.e. the pathoclisis of some hippocampal areas for neurofibrillary tangles and senile plaques, the pathoclisis of the IVth layer of calcarinian cortex for dyshoric angiopathia. These morphological pecularities must be correlated to more recent data concerning alterations of neurotransmitters and their enzymes.