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Review
. 2024 Apr;30(4):e13714.
doi: 10.1111/srt.13714.

Use of platelet rich plasma for skin rejuvenation

Lam Kar Wai Phoebe  1 , Kar Wai Alvin Lee  2 , Lisa Kwin Wah Chan  2 , Lee Cheuk Hung  2 , Raymond Wu  3 , Sky Wong  4 , Jovian Wan  3 , Kyu-Ho Yi  5   6
Affiliations
Review

Use of platelet rich plasma for skin rejuvenation

Lam Kar Wai Phoebe et al. Skin Res Technol. 2024 Apr.

Abstract

Objective: Platelet-rich plasma (PRP) is recognized as a safe and effective therapy for regenerative skin healing and rejuvenation, utilizing autologous blood enriched with various growth factors. This review aims to assess the efficacy of PRP treatments for skin rejuvenation.

Methods: Keywords such as "platelet-rich plasma," "rejuvenation," "skin aging," and "wrinkles" were queried on Ovid, PubMed, and MEDLINE to identify pertinent studies on PRP treatment for skin rejuvenation.

Results: Analysis revealed that PRP treatment led to significant enhancements in multiple facial parameters after one to three sessions. Improvements were noted in skin pore size, texture, wrinkle reduction, pigmented spots, collagen density, hyaluronic acid levels, and protection against ultraviolet damage. Combining PRP with hyaluronic acid demonstrated a synergistic effect, particularly enhancing skin elasticity in patients with lower body mass index and firmness in individuals aged 50s and 60s. Incorporating both physical and biometric data for assessment proved superior to relying solely on physical observations for evaluating subtle skin quality and structural changes.

Conclusion: This study underscores the efficacy of PRP monotherapy for skin rejuvenation and emphasizes the necessity of standardizing PRP preparation protocols in future investigations. Heightened awareness and advancements in technology have contributed to the emergence of higher-quality, less biased studies supporting PRP as a reliable and safe therapeutic option for skin rejuvenation.

Keywords: cell‐ and tissue‐based therapy; platelet‐rich plasma; rejuvenation; skin aging; wrinkling.

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Conflict of interest statement

I acknowledge that I have considered the conflict of interest statement included in the “Author Guidelines.” I hereby certify that, to the best of my knowledge, that no aspect of my current personal or professional situation might reasonably be expected to significantly affect my views on the subject I am presenting.

References

    1. Velarde MC, Flynn JM, Day NU, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012;4(1):3‐12. - PMC - PubMed
    1. Eppley BL, Pietrzak WS, Blanton M. Platelet‐rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg. 2006;118(6):147e‐147e. - PubMed
    1. Piipponen M, Li D, Landén NX. The immune functions of keratinocytes in skin wound healing. Int J Mol Sci. 2020; 21(22):8790. - PMC - PubMed
    1. Andia I, Abate M. Platelet‐rich plasma: underlying biology and clinical correlates. Regen Med. 2013;8(5):645‐658. - PubMed
    1. Alves R, Grimalt R. A review of platelet‐rich plasma: history, biology, mechanism of action, and classification. Skin Appendage Disord. 2018;4(1):18‐24. - PMC - PubMed

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