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Comparative Study
. 1985 Dec;82(23):7835-9.
doi: 10.1073/pnas.82.23.7835.

A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism

A R MacLeod, C Houlker, F C Reinach, L B Smillie, K Talbot, G Modi, F S Walsh
Comparative Study

A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism

A R MacLeod et al. Proc Natl Acad Sci U S A. 1985 Dec.

Abstract

We have isolated a cDNA clone from a human fibroblast cDNA library that contains the entire protein-coding region of a 1.1-kilobase mRNA. This mRNA encodes a 284-amino acid tropomyosin, the primary structure of which most closely resembles smooth muscle tropomyosin. Thus, the expression of both 284-amino acid muscle-type and 247-amino acid non-muscle-type tropomyosins appears to be a normal feature of human non-muscle cells. We also present evidence to suggest that this cytoskeletal tropomyosin and a human skeletal muscle beta-tropomyosin are derived from a common structural gene by an alternative RNA splicing mechanism.

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