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Case Reports
. 2024 Jul 1;46(5):e354-e359.
doi: 10.1097/MPH.0000000000002866. Epub 2024 Apr 23.

Variable Clinical Courses of Varicella Zoster Virus Infection-related or Vaccination-related Bone Marrow Failure

Vasil Toskov  1 , Annamaria Cseh  1   2 , Alexander Claviez  3 , Beatrice Drexler  1   4 , Natalia Rotari  1 , Stephan Schwarz-Furlan  5   6 , Matthias Braun  7 , Peter Bader  8 , Peter Lang  9 , Rita Beier  10 , Bernhard Erdlenbruch  11 , Monika Führer  12 , Miriam Erlacher  1 , Charlotte M Niemeyer  1 , Brigitte Strahm  1 , Ayami Yoshimi  1
Affiliations
Case Reports

Variable Clinical Courses of Varicella Zoster Virus Infection-related or Vaccination-related Bone Marrow Failure

Vasil Toskov et al. J Pediatr Hematol Oncol. .

Abstract

We report 5 children with bone marrow failure (BMF) after primary varicella zoster virus (VZV) infection or VZV vaccination, highlighting the highly variable course. Two patients were treated with intravenous immunoglobulins; one had a slow hematologic recovery, and the other was rescued by allogeneic hematopoietic stem cell transplantation (HSCT). Of the 2 patients treated with immunosuppressive therapy with antithymocyte globulin and cyclosporine, one had a complete response, and the other was transplanted for nonresponse. One patient underwent a primary allograft. All patients are alive. This study demonstrated that VZV-associated BMF is a life-threatening disorder that often requires HSCT.

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Conflict of interest statement

The authors declare conflict of interest.

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