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Review
. 2024 Apr 23;41(5):126.
doi: 10.1007/s12032-024-02310-y.

Challenges and strategies in relation to effective CAR-T cell immunotherapy for solid tumors

Guangxun Yuan #  1 , Mengke Ye #  1 , Yixi Zhang  2 , Xun Zeng  3
Affiliations
Review

Challenges and strategies in relation to effective CAR-T cell immunotherapy for solid tumors

Guangxun Yuan et al. Med Oncol. .

Abstract

Chimeric Antigen Receptor T cell (CAR-T) therapy has revolutionized cancer treatment, but its application to solid tumors is limited. CAR-T cells have poor incapability of entering, surviving, proliferating, and finally exerting function in the tumor microenvironment. This review summarizes the main strategies related to enhancing the infiltration, efficacy, antigen recognition, and production of CAR-T in solid tumors. Additional applications of CAR-γδ T and macrophages are also discussed. We believe CAR-T will be a milestone in treating solid tumors once these problems are solved.

Keywords: Antigen recognition; CAR-T; Efficacy; Infiltration; Tumor microenvironment.

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