Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Apr 23;41(5):126.
doi: 10.1007/s12032-024-02310-y.

Challenges and strategies in relation to effective CAR-T cell immunotherapy for solid tumors

Guangxun Yuan #  1 , Mengke Ye #  1 , Yixi Zhang  2 , Xun Zeng  3
Affiliations
Review

Challenges and strategies in relation to effective CAR-T cell immunotherapy for solid tumors

Guangxun Yuan et al. Med Oncol. .

Abstract

Chimeric Antigen Receptor T cell (CAR-T) therapy has revolutionized cancer treatment, but its application to solid tumors is limited. CAR-T cells have poor incapability of entering, surviving, proliferating, and finally exerting function in the tumor microenvironment. This review summarizes the main strategies related to enhancing the infiltration, efficacy, antigen recognition, and production of CAR-T in solid tumors. Additional applications of CAR-γδ T and macrophages are also discussed. We believe CAR-T will be a milestone in treating solid tumors once these problems are solved.

Keywords: Antigen recognition; CAR-T; Efficacy; Infiltration; Tumor microenvironment.

PubMed Disclaimer

References

    1. Albelda SM. CAR T cell therapy for patients with solid tumors: key lessons to learn and unlearn. Nat Rev Clin Oncol. 2023;21:47–66. - PubMed - DOI
    1. Li G, et al. IL-7 and CCR2b co-expression-mediated enhanced CAR-T survival and infiltration in solid tumors. Front Oncol. 2021;11: 734593. - PubMed - PMC - DOI
    1. Wang Y, et al. Chemokine receptor CCR2b enhanced anti-tumor function of chimeric antigen receptor T cells targeting mesothelin in a non-small-cell lung carcinoma model. Front Immunol. 2021;12: 628906. - PubMed - PMC - DOI
    1. Moon EK, et al. Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor. Clin Cancer Res Off J Am Assoc Cancer Res. 2011;17(14):4719–30. - DOI
    1. Whilding LM, et al. CAR T-cells targeting the integrin αvβ6 and co-expressing the chemokine receptor CXCR2 demonstrate enhanced homing and efficacy against several solid malignancies. Cancers. 2019;11(5):674. - PubMed - PMC - DOI

Substances

LinkOut - more resources