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Review
. 2024 Apr;82(4):1-9.
doi: 10.1055/s-0044-1786026. Epub 2024 Apr 23.

Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 1

Camila Henriques de Aquino  1   2   3 , Mariana Moscovich  4 , Murilo Martinez Marinho  3 , Lorena Broseghini Barcelos  3 , André C Felício  5 , Matthew Halverson  6 , Clement Hamani  7 , Henrique Ballalai Ferraz  3 , Renato Puppi Munhoz  8
Affiliations
Review

Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 1

Camila Henriques de Aquino et al. Arq Neuropsiquiatr. 2024 Apr.

Abstract
in English, Portuguese

Deep brain stimulation (DBS) is recognized as an established therapy for Parkinson's disease (PD) and other movement disorders in the light of the developments seen over the past three decades. Long-term efficacy is established for PD with documented improvement in the cardinal motor symptoms of PD and levodopa-induced complications, such as motor fluctuations and dyskinesias. Timing of patient selection is crucial to obtain optimal benefits from DBS therapy, before PD complications become irreversible. The objective of this first part review is to examine the fundamental concepts of DBS for PD in clinical practice, discussing the historical aspects, patient selection, potential effects of DBS on motor and non-motor symptoms, and the practical management of patients after surgery.

Nas últimas três décadas, a estimulação cerebral profunda (ECP) se tornou um tratamento bem estabelecido para doença de Parkinson (DP) e outros transtornos do movimento. A eficácia a longo prazo na DP foi bem documentada para a melhora dos sintomas motores cardinais da DP e das complicações induzidas pelo uso do levodopa, como as flutuações motoras e as discinesias. O momento da seleção do paciente é crucial para se obter os benefícios ideais da ECP, antes que as complicações da DP se tornem irreversíveis. O objetivo desta primeira parte da revisão é examinar os conceitos fundamentais da ECP na prática clínica, discutindo os aspectos históricos, a seleção de pacientes, os potenciais efeitos da ECP nos sintomas motores e não motores da doença e o manejo prático dos pacientes após a cirurgia.

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Conflict of interest statement

There is no conflict of interest to declare.

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