Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Apr;82(4):1-9.
doi: 10.1055/s-0044-1786037. Epub 2024 Apr 23.

Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 2

Mariana Moscovich  1 , Camila Henriques de Aquino  2   3   4 , Murilo Martinez Marinho  4 , Lorena Broseghini Barcelos  4 , André C Felício  5 , Matthew Halverson  6 , Clement Hamani  7 , Henrique Ballalai Ferraz  4 , Renato Puppi Munhoz  8
Affiliations
Review

Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 2

Mariana Moscovich et al. Arq Neuropsiquiatr. 2024 Apr.

Abstract
in English, Portuguese

The field of neuromodulation has evolved significantly over the past decade. Developments include novel indications and innovations of hardware, software, and stimulation techniques leading to an expansion in scope and role of these techniques as powerful therapeutic interventions. In this review, which is the second part of an effort to document and integrate the basic fundamentals and recent successful developments in the field, we will focus on classic paradigms for electrode placement as well as new exploratory targets, mechanisms of neuromodulation using this technique and new developments, including focused ultrasound driven ablative procedures.

O campo da neuromodulação evoluiu significativamente na última década. Esse progresso inclui novas indicações e inovações de hardware, software e técnicas de estimulação, levando a uma expansão das áreas clínicas cobertas e no papel dessas técnicas como intervenções terapêuticas eficazes. Nesta revisão, que é a segunda parte de um esforço para documentar e integrar os fundamentos básicos e os desenvolvimentos recentes e bem-sucedidos no campo, vamos nos concentrar em paradigmas clássicos para colocação de eletrodos, bem como em novos alvos exploratórios, mecanismos de neuromodulação usados por esta técnica e novos desenvolvimentos, incluindo procedimentos ablativos orientados por ultrassom focalizado.

PubMed Disclaimer

Conflict of interest statement

There is no conflict of interest to declare.

References

    1. Strauss I, Kalia S K, Lozano A M. Where are we with surgical therapies for Parkinson's disease? Parkinsonism Relat Disord. 2014;20 01:S187–S191. doi: 10.1016/S1353-8020(13)70044-0. - DOI - PubMed
    1. Vedam-Mai V, Deisseroth K, Giordano Jet al. Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies. Front Hum Neurosci. 2021;15:644593. - PMC - PubMed
    1. Khan S, Mooney L, Plaha P et al. Outcomes from stimulation of the caudal zona incerta and pedunculopontine nucleus in patients with Parkinson's disease. Br J Neurosurg. 2011;25(02):273–280. doi: 10.3109/02688697.2010.544790. - DOI - PubMed
    1. Stefani A, Lozano A M, Peppe Aet al. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease Brain 2007130(Pt 6):1596–1607. 10.1093/brain/awl346 - DOI - PubMed
    1. Khan S, Javed S, Mooney L et al. Clinical outcomes from bilateral versus unilateral stimulation of the pedunculopontine nucleus with and without concomitant caudal zona incerta region stimulation in Parkinson's disease. Br J Neurosurg. 2012;26(05):722–725. doi: 10.3109/02688697.2012.659297. - DOI - PubMed