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Meta-Analysis
. 2024 Sep;30(6):3813-3827.
doi: 10.1111/odi.14956. Epub 2024 Apr 24.

Xanthan-based chlorhexidine gel effects in non-surgical periodontal therapy? A meta-analysis

Magda Mensi  1 , Antonino Palazzolo  2 , Gianluca Garzetti  1 , Diego Lops  2 , Stefano Calza  3 , Matteo Rota  3
Affiliations
Free article
Meta-Analysis

Xanthan-based chlorhexidine gel effects in non-surgical periodontal therapy? A meta-analysis

Magda Mensi et al. Oral Dis. 2024 Sep.
Free article

Abstract

Objective: To carry out a systematic review and meta-analysis of randomized controlled clinical trials (RCTs) and controlled clinical trials (CCTs) comparing scaling and root planing (SRP) or placebo with subgingival application of xanthan-based CHX (chlorhexidine) gel as adjunct to SRP.

Materials and methods: The literature search was carried out in PubMed/MEDLINE, EMBASE, and SCOPUS; primary outcomes were probing pocket depth (PPD) reduction and gain in clinical attachment level (CAL).

Results: Overall, 15 studies were included. Three studies were judged to be at moderate risk of bias while the remaining 12 were rated at high risk of bias. A significant improvement in PPD reduction (standardized mean difference, SMD, 0.87, 95% CI, 0.41-1.34) and CAL gain (SMD = 0.84, 95% CI, 0.36-1.33) emerged for the SRP + CXH gel compared to the SRP alone group, in the presence of significant high heterogeneity among the studies.

Conclusions: Our systematic review and meta-analysis showed that xanthan-based chlorhexidine gel as adjunct to non-surgical periodontal therapy gives benefit in terms of PPD reduction and CAL gain as compared to non-surgical periodontal therapy only. Since there was high heterogeneity among studies and the quality of the evidence is low, further studies characterized by a better methodology, adequate sample size and longer follow-up are warranted in the next future.

Registration: The protocol of this scoping review was registered in the International Prospective Register of Systematic Reviews (https://www.crd.york.ac.uk/PROSPERO) with ID: CRD42023391589.

Keywords: non‐surgical therapy; periodontitis; xanthan‐based chlorhexidine gel.

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References

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