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Randomized Controlled Trial
. 2024 Apr 24:104:adv24360.
doi: 10.2340/actadv.v104.24360.

Filaggrin Mutation Status and Prevention of Atopic Dermatitis with Maternal Probiotic Supplementation

Dinastry Pramadita Zakiudin  1 , Jacob P Thyssen  2 , Claus Zachariae  3 , Vibeke Videm  4 , Torbjørn Øien  5 , Melanie Rae Simpson  5
Affiliations
Randomized Controlled Trial

Filaggrin Mutation Status and Prevention of Atopic Dermatitis with Maternal Probiotic Supplementation

Dinastry Pramadita Zakiudin et al. Acta Derm Venereol. .

Abstract

The World Allergy Organization recommends probiotics in the prevention of atopic dermatitis in high-risk populations. Mutations in the filaggrin gene (FLG) result in an increased risk of atopic dermatitis through disruption of the skin keratin layer. This exploratory study investigated whether the preventive effect of maternal probiotics was evident in children with and without FLG mutations. DNA was collected from children (n = 228) from the Probiotic in the Prevention of Allergy among Children in Trondheim (ProPACT) study. Samples were analysed for 3 common FLG mutations (R501X, R2447X, and 2282del4). Overall, 7% of children had heterozygous FLG mutations; each child had only one of the 3 mutations. Mutation status had no association with atopic dermatitis (RR = 1.1; 95% CI 0.5 to 2.3). The risk ratio (RR) for having atopic dermatitis following maternal probiotics was 0.6 (95% CI 0.4 to 0.9) and RR was similar if the child expressed an FLG mutation (RR = 0.6; 95% CI 0.1 to 4.1) or wildtype FLG (RR = 0.6; 95% CI 0.4 to 0.9). The preventive effect of probiotics for atopic dermatitis was also evident in children without FLG mutation. Larger confirmatory studies are needed.

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Conflict of interest statement

The authors have no conflicts of interests to declare.

Figures

Fig. 1
Fig. 1
Inclusion of the participants. Flow of subjects in the probiotic and placebo groups.
See this image and copyright information in PMC

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