Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research
- PMID: 38656304
- DOI: 10.1515/cclm-2023-1245
Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research
Abstract
Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging research technologies that uniquely characterize gene expression microenvironments on a cellular or subcellular level. The skin, a clinically accessible tissue composed of diverse, essential cell populations, serves as an ideal target for these high-resolution investigative approaches. Using these tools, researchers are assembling a compendium of data and discoveries in healthy skin as well as a range of dermatologic pathophysiologies, including atopic dermatitis, psoriasis, and cutaneous malignancies. The ongoing advancement of single-cell approaches, coupled with anticipated decreases in cost with increased adoption, will reshape dermatologic research, profoundly influencing disease characterization, prognosis, and ultimately clinical practice.
Keywords: gene expression; single cell transcriptomics; skin; spatial transcriptomics.
© 2024 Walter de Gruyter GmbH, Berlin/Boston.
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