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Review
. 2024 Apr 25;62(10):1880-1891.
doi: 10.1515/cclm-2023-1245. Print 2024 Sep 25.

Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research

Samuel Schepps  1 , Jonathan Xu  1 , Henry Yang  1 , Jenna Mandel  1 , Jaanvi Mehta  1 , Julianna Tolotta  1 , Nicole Baker  1 , Volkan Tekmen  1 , Neda Nikbakht  1   2 , Paolo Fortina  2   3 , Ignacia Fuentes  3   4 , Bonnie LaFleur  3   5 , Raymond J Cho  3   6 , Andrew P South  2   3
Affiliations
Free article
Review

Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research

Samuel Schepps et al. Clin Chem Lab Med. .
Free article

Abstract

Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging research technologies that uniquely characterize gene expression microenvironments on a cellular or subcellular level. The skin, a clinically accessible tissue composed of diverse, essential cell populations, serves as an ideal target for these high-resolution investigative approaches. Using these tools, researchers are assembling a compendium of data and discoveries in healthy skin as well as a range of dermatologic pathophysiologies, including atopic dermatitis, psoriasis, and cutaneous malignancies. The ongoing advancement of single-cell approaches, coupled with anticipated decreases in cost with increased adoption, will reshape dermatologic research, profoundly influencing disease characterization, prognosis, and ultimately clinical practice.

Keywords: gene expression; single cell transcriptomics; skin; spatial transcriptomics.

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