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Comment
. 2024 Apr 30;121(18):e2405380121.
doi: 10.1073/pnas.2405380121. Epub 2024 Apr 24.

Toward next-generation molecular imaging

Boyd M Goodson  1 , Eduard Y Chekmenev  2
Affiliations
Comment

Toward next-generation molecular imaging

Boyd M Goodson et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interests statement:B.M.G. and E.Y.C. declare a stake of ownership in XeUS Technologies, Ltd. E.Y.C. holds stock of Vizma Life Sciences (VLS) and serves on the Scientific Advisory Board (SAB) of VLS. B.M.G. and E.Y.C. have multiple pending and awarded patents in the area of NMR hyperpolarization.

Figures

Fig. 1.
Fig. 1.
The concept of metabolic imaging using HP MRI contrast agents and a schematic of SABRE hyperpolarization. Metabolic mapping of injected HP [1-13C]pyruvate and downstream metabolites enables imaging of aberrant metabolic fluxes in cancer and other metabolically challenged diseases. Simultaneous chemical exchange of parahydrogen (the source of NMR hyperpolarization) and a to-be-HP substrate (i.e., a contrast agent molecule) with a metal center results in hyperpolarization of “free” contrast agent molecules in solution over multiple exchange cycles.
See this image and copyright information in PMC

Comment on

  • Multi-axis fields boost SABRE hyperpolarization.
    Lindale JR, Smith LL, Mammen MW, Eriksson SL, Everhart LM, Warren WS. Lindale JR, et al. Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2400066121. doi: 10.1073/pnas.2400066121. Epub 2024 Mar 27. Proc Natl Acad Sci U S A. 2024. PMID: 38536754 Free PMC article.

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