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. 2024 Jun:118:101-112.
doi: 10.1016/j.sleep.2024.03.047. Epub 2024 Mar 31.

Nocturnal oxygen resaturation parameters are associated with cardiorespiratory comorbidities

Timothy P Howarth  1 , Saara Sillanmäki  2 , Tuomas Karhu  3 , Marika Rissanen  4 , Anna Sigridur Islind  5 , Harald Hrubos-Strøm  6 , Philip de Chazal  7 , Juuso Huovila  8 , Samu Kainulainen  3 , Timo Leppänen  9
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Free article

Nocturnal oxygen resaturation parameters are associated with cardiorespiratory comorbidities

Timothy P Howarth et al. Sleep Med. 2024 Jun.
Free article

Abstract

Background: There are strong associations between oxygen desaturations and cardiovascular outcomes. Additionally, oxygen resaturation rates are linked to excessive daytime sleepiness independent of oxygen desaturation severity. No studies have yet looked at the independent effects of comorbidities or medications on resaturation parameters.

Methods: The Sleep Heart Health Study data was utilised to derive oxygen saturation parameters from 5804 participants. Participants with a history of comorbidities or medication usage were compared against healthy participants with no comorbidity/medication history.

Results: 4293 participants (50.4% female, median age 64 years) were included in the analysis. Females recorded significantly faster resaturation rates (mean 0.61%/s) than males (mean 0.57%/s, p < 0.001), regardless of comorbidities. After adjusting for demographics, sleep parameters, and desaturation parameters, resaturation rate was reduced with hypertension (-0.09 (95% CI -0.16, -0.03)), myocardial infarction (-0.13 (95% CI -0.21, -0.04)) and heart failure (-0.19 (95% CI -0.33, -0.05)), or when using anti-hypertensives (-0.10 (95% CI -0.17, -0.03)), mental health medications (-0.18 (95% CI -0.27, -0.08)) or anticoagulants (-0.41 (95% CI -0.56, -0.26)). Desaturation to Resaturation ratio for duration was decreased with mental health (-0.21 (95% CI -0.34, -0.08)) or diabetic medications (-0.24 (95% CI -0.41, -0.07)), and desaturation to resaturation ratio for area decreased with heart failure (-0.25 (95% CI -0.42, -0.08)).

Conclusions: Comorbidities and medications significantly affect nocturnal resaturation parameters, independent of desaturation parameters. However, the causal relationship remains unclear. Further research can enhance our knowledge and develop more precise and safer interventions for individuals affected by certain comorbidities.

Keywords: Cardiorespiratory comorbidities; Oxygen saturation; Polysomnography; Resaturation.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Timo Leppänen reports financial support was provided by Nordforsk. Timo Leppänen reports financial support was provided by Kuopio University Hospital. Saara Sillanmäki reports financial support was provided by Kuopio University Hospital. Marika Rissanen reports financial support was provided by Kuopio Area Respiratory Foundation. Harald Hrubos-Strøm reports financial support was provided by Nordforsk. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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