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Multicenter Study
. 2024 Apr;45(4):369-378.
doi: 10.15537/smj.2024.45.4.20230741.

Risk factors for severe bronchopulmonary dysplasia in a Chinese cohort of very preterm infants

Jing Huang  1 , Wei Shen  1 , Fan Wu, Jian Mao  1 , Ling Liu, Yanmei Chang  1 , Rong Zhang  1 , Xiuzhen Ye  1 , Yinping Qiu, Li Ma  1 , Rui Cheng  1 , Hui Wu, Dongmei Chen  1 , Ling Chen  1 , Ping Xu  1 , Hua Mei  1 , Sannan Wang  1 , Falin Xu  1 , Rong Ju  1 , Zhi Zheng  1 , Xinzhu Lin  1 , Xiaomei Tong  1
Affiliations
Multicenter Study

Risk factors for severe bronchopulmonary dysplasia in a Chinese cohort of very preterm infants

Jing Huang et al. Saudi Med J. 2024 Apr.

Abstract

Objectives: To examine the risk factors for severe bronchopulmonary dysplasia (BPD) in a cohort of very preterm infants (VPIs) in China, as BPD is common among VPIs and associated with a high mortality rate.

Methods: In this multicenter retrospective study, medical records from infants with BPD born at gestation age (GA) of <32 weeks with birth weight (BW) of <1,500 grams (g) in 7 regions of China were included. The cohort was stratified into different BPD severity groups based on their fraction of inspired oxygen requirement at a modified GA of 36 weeks or post discharge. Risk factors were identified using logistic regression analysis.

Results: A significant inverse correlation was revealed between BPD severity and both GA and BW (p<0.001). Independent risk factors for severe BPD (sBPD) were identified as invasive mechanical ventilation (≥7d), multiple blood transfusion (≥3), nosocomial infection (NI), hemodynamically significant patent ductus arteriosus (hsPDA), delayed initiation of enteral nutrition, and longer time to achieve total caloric intake of 110 kcal/kg. Conversely, administration of antenatal steroids was associated with reduced risk of sBPD.

Conclusion: Our study not only reaffirmed the established risk factors of low GA and BW for sBPD in VPIs, but also identified additional, potentially modifiable risk factors. Further research is warranted to explore whether intervention in these modifiable factors might reduce the risk of sBPD.Clinical Trial Reg. No.: ChiCTR1900023418.

Keywords: bronchopulmonary dysplasia; nutrition; risk factor; very preterm infants; very-low-birth-weight infants.

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Figures

Figure 1
Figure 1
- A flow chart of the infant selection process. NICUs: neonatal intensive care units, BW: birth weight, NICHD: the National Institute of Child Health and Human Development, BPD: bronchopulmonary dysplas
Figure 2
Figure 2
- Histogram of bronchopulmonary dysplasia incidence according to severity by: A) weeks of gestational age at birth and B) birth weight. BPD: bronchopulmonary dysplasia
See this image and copyright information in PMC

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