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. 2024 Apr;14(4):e1669.
doi: 10.1002/ctm2.1669.

AdjuvareDB: A comprehensive database for candidate adjuvant compendium in clinic

[Article in Romanian]
Dekang Ren  1 , Jiaming Jin  1 , Shizheng Xiong  1 , Daoliang Xia  1 , Xinmiao Zhao  1 , Haochuan Guo  2 , Xueni Yang  1 , Jiafeng Yu  3 , Tingming Liang  2 , Li Guo  1
Affiliations

AdjuvareDB: A comprehensive database for candidate adjuvant compendium in clinic

[Article in Romanian]
Dekang Ren et al. Clin Transl Med. 2024 Apr.
No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
The schematic workflow of data collection and main frame of AdjuvareDB.
FIGURE 2
FIGURE 2
The primary analysis of candidate adjuvants. A. The annotation of candidate adjuvants in AdjuvareDB. B. The distribution of adjuvant and cancer application types based on 104 clinical trial protocols for therapeutic cancer vaccines. C. The alluvial plot of adjuvants involved in therapeutic cancer vaccine trial protocols and the types of cancers targeted, as obtained from ClinicalTrials.gov (https://classic.clinicaltrials.gov/), showing the relationships of National Clinical Trial (NCT) number, adjuvant name, and cancer type among the high frequency of 7 adjuvants used in the trials. Abbreviations: rhGM‐CSF, recombinant human granulocyte‐macrophage colony‐stimulating factor; IFA, Incomplete Freund's Adjuvant; QS21, Quillaja saponaria Molina; CpG‐ODN, cytosine‐phosphodiester‐guanine‐oligonucleotide; Poly IC: LC, Poly‐L‐lysine and carboxymethyl cellulose; NSCLC, Non−Small Cell Lung Carcinoma.
FIGURE 3
FIGURE 3
Primary analysis of gene set indicates the roles in tumorigenesis. A. The distributions of the associations between immune cell infiltration and expression level of the gene set identified as potential genetic adjuvants. * indicates significant correlations, r > 0.40 or r < ‐0.40 and FDR < 0.05. B. Bar plot shows distribution of enrichment score via GSEA (Gene Set Enrichment Analysis) in pan‐cancer based on the get set. Significant padj values are presented for some specific cancer types. The right images show enrichment plots in ESCA and KIRC. Abbreviations of cancers: ACC, Adrenocortical carcinoma; BLCA, Bladder Urothelial Carcinoma; BRCA, Breast invasive carcinoma; CESC, Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, Cholangiocarcinoma; COAD, Colon adenocarcinoma; DLBC, Lymphoid Neoplasm Diffuse Large B‐cell Lymphoma; ESCA, Esophageal carcinoma; GBM, Glioblastoma multiforme; LGG, Glioma; HNSC, Head and Neck squamous cell carcinoma; KICH, Kidney Chromophobe; KIRC, Kidney renal clear cell carcinoma; KIRP, Kidney renal papillary cell carcinoma; LAML, Acute Myeloid Leukemia; LGG, Brain Lower Grade Glioma; LIHC, Liver hepatocellular carcinoma; LUAD, Lung adenocarcinoma; LUSC, Lung squamous cell carcinoma; MESO, Mesothelioma; OV, Ovarian serous cystadenocarcinoma; PAAD, Pancreatic adenocarcinoma; PCPG, Pheochromocytoma and Paraganglioma; PRAD, Prostate adenocarcinoma; READ, Rectum adenocarcinoma; SARC, Sarcoma; SKCM, Skin Cutaneous Melanoma.
FIGURE 4
FIGURE 4
The main search module of AdjuvareDB. The main search module and the detailed information for specific adjuvant are presented here. Some candidate genetic adjuvants are also connected KEGG database and STRING database.
See this image and copyright information in PMC

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