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. 1985 Oct;74(10):1097-9.
doi: 10.1002/jps.2600741017.

Pharmacokinetic scale-up: accurate prediction of human pharmacokinetic profiles from animal data

Pharmacokinetic scale-up: accurate prediction of human pharmacokinetic profiles from animal data

J Mordenti. J Pharm Sci. 1985 Oct.

Abstract

Ceftizoxime pharmacokinetic parameters from mice, rats, monkeys, and dogs were scaled allometrically and used to predict the value of each parameter in a 70-kg human. Three methods of interspecies pharmacokinetic scale-up provided accurate simulations of the human biexponential serum concentration-time profiles for a 1-g iv bolus and a 4-g, 30-min intravenous infusion. Successful scale-up of animal pharmacokinetic data can have tremendous impact during the preclinical assessment of new pharmaceutical compounds by providing reasonable estimates of pharmacokinetic parameters in humans.

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