[Cefmenoxime concentrations in human blood, bile and gallbladder in administration before surgery]

Abstract

The pharmacokinetics of cefmenoxime (CMX) were studied in 13 patients with cholecystolithiasis, 6 male and 7 female, ranging from 27 to 69 years of age. All patients received a single intravenous dose of CMX 2 g given in a drip infusion over 30 minutes. The level of CMX in gallbladder tissues fell from 350 +/- 101 micrograms/g (mean concentrations, 2.7 hours after administration) to 68 +/- 13 micrograms/g by 7.2 hours. In bile, the mean concentrations of CMX, 2,595 +/- 624 micrograms/ml were reached at 2.7 hours after administration, and at 7.2 hours the mean concentrations were 103 +/- 60 micrograms/ml. In the study reported here, a single 2 g dose of CMX was administered intravenously, and high concentrations of CMX in gallbladder tissue and bile were reached at 2.7 hours after administration. These results suggested that the administration of CMX at about 2.5 hours before surgery might be most effective for prophylaxis.