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. 2024 May 1;72(5):617-619.
doi: 10.4103/IJO.IJO_2166_23. Epub 2024 Apr 22.

Off-label use of intravitreal bevacizumab: A global conundrum

Samya Singh  1 , Sandeep Saxena  1 , Levent Akduman  2 , Carsten H Meyer  3
Affiliations

Off-label use of intravitreal bevacizumab: A global conundrum

Samya Singh et al. Indian J Ophthalmol. .

Abstract

Bevacizumab is a monoclonal, humanized, full-length antibody targeting vascular endothelial growth factor(VEGF-A), known for its anti-angiogenic properties. The off-label use of bevacizumab has stirred legal, financial, industrial, and ethical complexities. With its potential to treat diverse ocular conditions, this commentary delves into the multifaceted dimensions of bevacizumab's off-label utilization, encompassing clinical trials, regulatory frameworks, safety considerations, comparative effectiveness, and economic implications.

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Conflict of interest statement

There are no conflicts of interest.

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