Effects of some antidepressant drugs on apomorphine concentration in the central nervous system of rats and apomorphine-induced stereotypy

Abstract

Pharmacokinetic aspects of interaction between antidepressant drugs (AD) and apomorphine (APO) have been studied. It was found that neither acute nor chronic AD pretreatment affected the distribution of APO-induced stereotypy was not changed. An exception was citalopram (CIT) which given in a single dose to rats significantly potentiated APO-induced gnawing. Single dose of investigated AD delayed the onset of APO-induced sniffing, licking and gnawing, however the overall effect did not reach the statistically significant level. The presented results suggest that changes of APO behavioral effects induced by AD pretreatment are rather due to pharmacodynamic and not pharmacokinetic interaction.