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Comparative Study
. 2024 Apr 1;65(4):39.
doi: 10.1167/iovs.65.4.39.

Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma

Roxana M Hicks  1   2 , Xunda Ji  3 , Yihua Zou  3 , Sadia Sultana  4 , Riffat Rashid  4 , Sadik T Sherief  5 , Nathalie Cassoux  6 , Juan L Garcia Leon  7 , Rosdali Y Diaz Coronado  8 , Arturo M Z López  8 , Tatiana L Ushakova  9   10 , Vladimir G Polyakov  9   10 , Soma R Roy  11 , Alia Ahmad  12 , M Ashwin Reddy  13   14 , Mandeep S Sagoo  13   14   15 , Lamis Al Harby  13 , Jesse L Berry  16   17 , Ashley Polski  16   17 , Nicholas J Astbury  18 , Covadonga Bascaran  18 , Sharon Blum  19 , Richard Bowman  18   20 , Matthew J Burton  15   18 , Nir Gomel  21 , Naama Keren-Froim  19 , Shiran Madgar  19 , Marcia Zondervan  18 , Swathi Kaliki  22 , Ido D Fabian  18   19 , Andrew W Stacey  1   23
Affiliations
Comparative Study

Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma

Roxana M Hicks et al. Invest Ophthalmol Vis Sci. .

Abstract

Purpose: Little is known regarding differences in childhood growth between somatic and heritable retinoblastoma (Rb) populations. We aimed to compare childhood growth parameters between somatic and heritable Rb cohorts at birth and at time of diagnosis with Rb.

Methods: A multinational, longitudinal cohort study was conducted with patients from 11 centers in 10 countries who presented with treatment naïve Rb from January to December 2019. Variables of interest included age, sex, and size characteristics at birth and at time of presentation, as well as germline mutation status. After Bonferroni correction, results were statistically significant if the P value was less than 0.005.

Results: We enrolled 696 patients, with 253 analyzed after exclusion criteria applied. Between somatic (n = 39) and heritable (n = 214) Rb cohorts, with males and females analyzed separately, there was no significant difference in birth weight percentile, weight percentile at time of diagnosis, length percentile at time of diagnosis, weight-for-length percentile at time of diagnosis, or change of weight percentile from birth to time of diagnosis. Patients with heritable Rb had a smaller mean weight percentile at birth and smaller mean weight and length percentiles at time of diagnosis with Rb, although this difference was not statistically significant. All cohorts experienced a slight negative change of weight percentile from birth to time of diagnosis. No cohort mean percentiles met criteria for failure to thrive, defined as less than the 5th percentile.

Conclusions: Children with Rb seem to have normal birth and childhood growth patterns. There is no definitive evidence that somatic or heritable Rb has a biological or environmental impact on childhood growth parameters.

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Conflict of interest statement

Disclosure: R.M. Hicks, None; X. Ji, None; Y. Zou, None; S. Sultana, None; R. Rashid, None; S.T. Sherief, None; N. Cassoux, None; J.L. Garcia Leon, None; R.Y. Diaz Coronado, None; A.M.Z. López, T.L. Ushakova, None; V.G. Polyakov, None; S.R. Roy, None; A. Ahmad, None; M.A. Reddy, None; M.S. Sagoo, None; L. Al Harby, None; J.L. Berry, None; A. Polski, None; N.J. Astbury, None; C. Bascaran, None; S. Blum, None; R. Bowman, None; M.J. Burton, None; N. Gomel, None; N. Keren-Froim, None; S. Madgar, None; M. Zondervan, None; S. Kaliki, None; I.D. Fabian, None; A.W. Stacey, None

Figures

Figure 1.
Figure 1.
Mean weight percentiles at birth. Mean weight percentile at birth was not significantly different between males with somatic and heritable Rb (P = 0.31), nor between females with somatic and heritable Rb (P = 0.35).
Figure 2.
Figure 2.
Mean weight, length, and weight for length percentiles at time of diagnosis with Rb. At time of diagnosis with Rb, there was no significant difference between males with somatic and heritable Rb in weight (P = 0.04), length (P = 0.10), or weight-for-length percentile (P = 0.78). There was no significant difference between females with somatic and heritable Rb in weight (P = 0.23), length (P = 0.23), or weight-for-length percentile (P = 0.84) at time of diagnosis with Rb.
Figure 3.
Figure 3.
Mean change of weight percentile from birth to time of diagnosis with Rb. Mean change of weight percentile from birth to time of diagnosis with Rb was not significantly different between males with somatic and heritable Rb (P = 0.52), nor between females with somatic and heritable Rb (P = 0.52).
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