Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr 26;134(9):1228-1230.
doi: 10.1161/CIRCRESAHA.124.324419. Epub 2024 Apr 25.

Oral Polystyrene Consumption Potentiates Atherosclerotic Lesion Formation in ApoE-/- Mice

Jingjing Zhao  1   2 , Daniel Gomes  1   3 , Fangping Yuan  1 , Jing Feng  4   5 , Xiang Zhang  2   4   5 , Timothy E O'Toole  1   2
Affiliations

Oral Polystyrene Consumption Potentiates Atherosclerotic Lesion Formation in ApoE-/- Mice

Jingjing Zhao et al. Circ Res. .
No abstract available

Keywords: atherosclerosis; cardiovascular diseases; microplastics; polystyrenes.

PubMed Disclaimer

Conflict of interest statement

Disclosures None.

Figures

Figure 1.
Figure 1.. Polystyrene consumption potentiates atherosclerotic lesion development.
ApoE−/− mice were supplied with a chow diet and either normal water (N) or that containing polystyrene beads (PS: 0.5μm, 1μg/ml) for 20wks and then euthanized. A) Upper: Illustrated are representative heart valve sections stained with oil red O. Lower: Illustrated are group data (n=14-15). A Shapiro-Wilk test was used to determine normality, and statistical significance (*:p=0.016) was determined using a Student’s t-Test. B) Listed are plasma and metabolic parameters measured in the two groups of mice, their values, and statistical significance. C) Illustrated are the HOMA-IR scores for the two treatment groups. The groups were not significantly different as determined using a Mann-Whitney-Wilcoxon test. At euthanasia, aortae were collected from the exposed mice and used for a transcriptomics analysis. Illustrated (D) is a gene ontology (GO) analysis of top 30 impacted functions, where the ordinate is the GO term and the abscissa is ratio of the differential gene number to the total number of differential genes on the GO Term; count = number of genes annotated to a given GO term. (E) Listed are the top 10 most up-regulated and down-regulated genes in the PS-exposed mice versus mice consuming normal water.
See this image and copyright information in PMC

References

    1. Barcelo D, Pico Y and Alfarhan AH. Microplastics: Detection in human samples, cell line studies, and health impacts. Environ Toxicol Pharmacol. 2023;101:104204. - PubMed
    1. Zhao J, Gomes D, Jin L, Mathis SP, Li X, Rouchka EC, Bodduluri H, Conklin DJ O’Toole TE. Polystyrene bead ingestion promotes adiposity and cardiometabolic disease in mice. Ecotoxicol Environ Saf. 2022;232:113239. - PMC - PubMed
    1. Zhao J, Adiele N, Gomes D, Malovichko M, Conklin DJ, Ekuban A, Luo J, Gripshover T, Watson WH, Banerjee M, et al. Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis. Toxicol Sci. 2024. - PMC - PubMed
    1. Huang H, Wei F, Qiu S, Xing B and Hou J. Polystyrene microplastics trigger adiposity in mice by remodeling gut microbiota and boosting fatty acid synthesis. Sci Total Environ. 2023;890:164297. - PubMed
    1. Benitez R, Delgado-Maroto V, Caro M, Forte-Lago I, Duran-Prado M, O’Valle F, Lichtman AH, Gonzalez-Rey E and Delgado M. Vasoactive Intestinal Peptide Ameliorates Acute Myocarditis and Atherosclerosis by Regulating Inflammatory and Autoimmune Responses. J Immunol. 2018;200:3697–3710. - PubMed

Publication types