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Multicenter Study
. 2024 Oct;44(10):1496-1503.
doi: 10.1038/s41372-024-01968-6. Epub 2024 Apr 25.

Association between early echocardiography screening of low systemic blood flow and intraventricular hemorrhage in preterm infants: a multicenter cohort study

Sandra Terroba-Seara #  1   2 , Ignacio Oulego-Erroz #  3   4 , Daniel Palanca-Arias  5   6 , Zenaida Galve-Pradel  7 , Sara Delgado-Nicolás  8 , Alicia Pérez-Pérez  8 , Jorge Rodríguez-Ozcoidi  9 , Ana Lavilla-Oíz  9 , María Carmen Bravo  10   11 , Leticia La Banda-Montalvo  10   11 , Paula Méndez-Abad  12 , Pamela Zafra-Rodríguez  12 , Lorena Rodeño-Fernández  13 , Jon Montero-Gato  13 , Carmen Bustamante-Hervás  14 , Cristina Vega-Del-Val  14 , Javier Rodríguez-Fanjul  15 , Juan Mayordomo-Colunga  16   17   18 , Iosune Alegría-Echauri  9 , Andrea Pérez-Álvarez  19   20
Affiliations
Multicenter Study

Association between early echocardiography screening of low systemic blood flow and intraventricular hemorrhage in preterm infants: a multicenter cohort study

Sandra Terroba-Seara et al. J Perinatol. 2024 Oct.

Abstract

Objective: To determine whether early echocardiography screening of low systemic blood flow reduces intraventricular hemorrhage in preterm infants.

Study design: Prospective multicenter study in preterm infants below 33 weeks of gestational age at nine neonatal units. Five units performed early echocardiography screening for low systemic blood flow and guided clinical management (exposure group) and 4 units did not (control group). Our main outcome was ≥grade II intraventricular hemorrhage or death within the first 7 days of life. The main analysis used the inverse probability of treatment weighting.

Results: Three hundred and thirty-two preterm infants (131 in the exposure group and 201 in the control group) were included. Exposure to early echocardiography screening was associated with a significant reduction in ≥grade II intraventricular hemorrhage or early death [odds ratio 0.285 (95% CI: 0.133-0.611); p = 0.001].

Conclusions: Early echocardiography screening for low systemic blood flow may reduce the incidence of intraventricular hemorrhage in preterm infants.

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