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Review
. 2024 Apr 25;24(1):137.
doi: 10.1186/s12883-024-03645-9.

Guillain-Barre syndrome following scrub typhus: a case report and literature review

Shijun Hu #  1 , Zhichuan Lin #  1 , Tao Liu  1 , Shixiong Huang  1 , Hui Liang  2
Affiliations
Review

Guillain-Barre syndrome following scrub typhus: a case report and literature review

Shijun Hu et al. BMC Neurol. .

Abstract

Background: Scrub typhus is an acute infectious disease caused by Orientia tsutsugamushi. Guillain-Barre syndrome (GBS) is an autoimmune-mediated peripheral neuropathy with a frequent history of prodromal infections, but GBS associated with scrub typhus is very rare.

Case presentation: We report a 51-year-old male patient who developed dysarthria and peripheral facial paralysis following the cure of scfrub typhus. CSF examination and electrophysiological findings suggested a diagnosis of GBS. After treatment with intravenous immunoglobulin, the patient's neurological condition improved rapidly.

Conclusions: Scrub typhus infection is likely to be a potential predisposing factor in GBS, while scrub typhus-associated GBS has a favorable prognosis.

Keywords: Anti-sulfatide antibodies; Case report; Guillain–Barré syndrome; Neuropathy; Scrub typhus.

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Conflict of interest statement

The authors declare no competing interests.

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