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Review
. 2024 Apr 8;20(6):86.
doi: 10.3892/br.2024.1774. eCollection 2024 Jun.

A comprehensive assessment of toxoplasmosis and its dormant impact on psychotic disorders (Review)

Aliss Madalina Mares  1 , Corina Ioana Varlam  2 , Floris Petru Iliuta  1   2 , Radu Mihail Lacau  2 , Mihnea Costin Manea  1   2
Affiliations
Review

A comprehensive assessment of toxoplasmosis and its dormant impact on psychotic disorders (Review)

Aliss Madalina Mares et al. Biomed Rep. .

Abstract

Toxoplasmosis is a pathological condition induced by the parasite, Toxoplasma gondii (T. gondii), which has a notable affinity for the cellular components of the central nervous system. Over the decades, the relationship between toxoplasmosis and the development of psychiatric disorders has generated profound interest within the scientific community. Whether considering immunocompetent or immunocompromised patients, epidemiological studies suggest that exposure to T. gondii may be associated with a higher risk of certain psychiatric disorders. However, there are extensive debates regarding the exact nature of this association and how T. gondii is involved in the pathogenesis of these disorders. Toxoplasmosis has long been considered an asymptomatic infection among immunocompetent patients. However, there appears to be an association between chronic brain infection with T. gondii and alterations in patient neuronal architecture, neurochemistry and behavior. The present review aimed to compile statements and pathophysiological hypotheses regarding the potential association between toxoplasmosis and psychotic disorders. Further research is necessary for understanding the potential relationship of T. gondii infection and psychotic disorders.

Keywords: gene-environment interactions; pathophysiology; psychosis; risk factors; toxoplasma; toxoplasmosis.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Kotsiri I, Resta P, Spyrantis A, Panotopoulos C, Chaniotis D, Beloukas A, Magiorkinis E. Viral infections and schizophrenia: A comprehensive review. Viruses. 2023;15(1345) doi: 10.3390/v15061345. - DOI - PMC - PubMed
    1. Maisarah A, Mohamad S, Husain M, Abdullah S, Noordin R. Association between infection with Toxoplasma gondii and psychiatric disorders. Folia Parasitol (Praha) 2022;69(2022.008) doi: 10.14411/fp.2022.008. - DOI - PubMed
    1. Kim K, Weiss LM. Toxoplasma: The next 100 years. Microbes Infect. 2008;10:978–984. doi: 10.1016/j.micinf.2008.07.015. - DOI - PMC - PubMed
    1. Bisetegn H, Debash H, Ebrahim H, Mahmood N, Gedefie A, Tilahun M, Alemayehu E, Mohammed O, Feleke DG. Global seroprevalence of Toxoplasma gondii infection among patients with mental and neurological disorders: A systematic review and meta-analysis. Health Sci Rep. 2023;6(e1319) doi: 10.1002/hsr2.1319. - DOI - PMC - PubMed
    1. Flegr J. Effects of Toxoplasma on human behavior. Schizophr Bull. 2007;33:757–760. - PMC - PubMed