ALSUntangled #75: Portable neuromodulation stimulator therapy

Laurel Officer¹, Carmel Armon², Paul Barkhaus³, Morgan Beauchamp⁴, Michael Benatar⁵, Tulio Bertorini⁶, Robert Bowser⁷, Mark Bromberg⁸, Andrew Brown⁵, Olimpia Mihaela Carbunar⁵, Gregory T Carter⁹, Jesse Crayle¹⁰, Keelie Denson¹¹, Eva Feldman¹², Timothy Fullam¹, Terry Heiman-Patterson¹³, Carlayne Jackson¹⁴, Sartaj Jhooty¹⁵, Danelle Levinson¹⁶, Xiaoyan Li¹⁷, Alexandra Linares¹⁶, Elise Mallon¹⁸, Javier Mascias Cadavid¹⁹, Christopher Mcdermott²⁰, Tasnim Mushannen¹⁷, Lyle Ostrow¹³, Ronak Patel¹, Gary Pattee²¹, Dylan Ratner²², Yuyao Sun²³, John Sladky¹, Paul Wicks²⁴, Richard Bedlack¹⁷

Affiliations

¹ Department of Neurology, Brooke Army Medical Center, San Antonio, TX, USA.
² Department of Neurology, Shamir Medical Center, Tzrifin, Israel.
³ Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
⁴ UNC Neuroscience Clinical Trials Unit, Chapel Hill, NC, USA.
⁵ Department of Neurology, University of Miami, Miami, FL, USA.
⁶ Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.
⁷ Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
⁸ Department of Neurology, University of Utah, Salt Lake City, UT, USA.
⁹ Department of Rehabilitation, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
¹⁰ Department of Neurology, Washington University, St. Louis, MO, USA.
¹¹ Department of Neurology, Houston Methodist Hospital, Houston, TX, USA.
¹² Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
¹³ Department of Neurology, Temple Health, Philadelphia, PA, USA.
¹⁴ Department of Neurology, UT Health San Antonio, San Antonio, Texas, USA.
¹⁵ Department of Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹⁶ Medical School, Duke University, Durham, NC, USA.
¹⁷ Department of Neurology, Duke University, Durham, NC, USA.
¹⁸ Undergraduate, Duke University, Durham, NC, USA.
¹⁹ ALS Unit, Neurology Department, Hospital La Paz Institute for Health Research, Madrid, Spain.
²⁰ Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, UK.
²¹ Department of Neurology, University of Nebraska Medical Center, Omaha, NE, USA.
²² Undergraduate, Tulane University, New Orleans, LA, USA.
²³ Department of Neurology, University of Kentucky, Lexington, KY, USA, and.
²⁴ Independent Consultant, Lichfield, England, UK.

PMID: 38666601
DOI: 10.1080/21678421.2024.2346825

Review

ALSUntangled #75: Portable neuromodulation stimulator therapy

Laurel Officer et al. Amyotroph Lateral Scler Frontotemporal Degener. 2024 Aug.

. 2024 Aug;25(5-6):648-652.

doi: 10.1080/21678421.2024.2346825. Epub 2024 Apr 26.

Authors

Affiliations

¹ Department of Neurology, Brooke Army Medical Center, San Antonio, TX, USA.
² Department of Neurology, Shamir Medical Center, Tzrifin, Israel.
³ Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
⁴ UNC Neuroscience Clinical Trials Unit, Chapel Hill, NC, USA.
⁵ Department of Neurology, University of Miami, Miami, FL, USA.
⁶ Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.
⁷ Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
⁸ Department of Neurology, University of Utah, Salt Lake City, UT, USA.
⁹ Department of Rehabilitation, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
¹⁰ Department of Neurology, Washington University, St. Louis, MO, USA.
¹¹ Department of Neurology, Houston Methodist Hospital, Houston, TX, USA.
¹² Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
¹³ Department of Neurology, Temple Health, Philadelphia, PA, USA.
¹⁴ Department of Neurology, UT Health San Antonio, San Antonio, Texas, USA.
¹⁵ Department of Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹⁶ Medical School, Duke University, Durham, NC, USA.
¹⁷ Department of Neurology, Duke University, Durham, NC, USA.
¹⁸ Undergraduate, Duke University, Durham, NC, USA.
¹⁹ ALS Unit, Neurology Department, Hospital La Paz Institute for Health Research, Madrid, Spain.
²⁰ Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, UK.
²¹ Department of Neurology, University of Nebraska Medical Center, Omaha, NE, USA.
²² Undergraduate, Tulane University, New Orleans, LA, USA.
²³ Department of Neurology, University of Kentucky, Lexington, KY, USA, and.
²⁴ Independent Consultant, Lichfield, England, UK.

PMID: 38666601
DOI: 10.1080/21678421.2024.2346825

Abstract

Spurred by patient interest, ALSUntangled herein examines the potential of the Portable Neuromodulation Stimulator (PoNS™) in treating amyotrophic lateral sclerosis (ALS). The PoNS™ device, FDA-approved for the treatment of gait deficits in adult patients with multiple sclerosis, utilizes translingual neurostimulation to stimulate trigeminal and facial nerves via the tongue, aiming to induce neuroplastic changes. While there are early, promising data for PoNS treatment to improve gait and balance in multiple sclerosis, stroke, and traumatic brain injury, no pre-clinical or clinical studies have been performed in ALS. Although reasonably safe, high costs and prescription requirements will limit PoNS accessibility. At this time, due to the lack of ALS-relevant data, we cannot endorse the use of PoNS as an ALS treatment.

Keywords: Electrical stimulation; PoNS™ Device; neuromodulation.

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ALSUntangled #75: Portable neuromodulation stimulator therapy

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ALSUntangled #75: Portable neuromodulation stimulator therapy

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