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Review
. 2024 Apr 16;13(4):265.
doi: 10.3390/biology13040265.

Prognostic Electrocardiographic Signs in Arrhythmogenic Cardiomyopathy

Elisabetta Tonet  1 , Francesco Vitali  1 , Veronica Amantea  1 , Giorgia Azzolini  1 , Cristina Balla  1 , Marco Micillo  1 , Davide Lapolla  1 , Luca Canovi  1 , Matteo Bertini  1
Affiliations
Review

Prognostic Electrocardiographic Signs in Arrhythmogenic Cardiomyopathy

Elisabetta Tonet et al. Biology (Basel). .

Abstract

Arrhythmogenic cardiomyopathy (ACM) is a rare cardiac disease, characterized by the progressive replacement of myocardial tissue with fibrous and fatty deposits. It can involve both the right and left ventricles. It is associated with the development of life-threatening arrhythmias and culminates in sudden cardiac death. Electrocardiography (ECG) has emerged as a pivotal tool, offering diagnostic insights and prognostic information. The specific ECG abnormalities observed in ACM not only contribute to early detection but also hold the key to the prediction of the likelihood of severe complications. The recognition of these nuanced ECG manifestations has become imperative for clinicians as it guides them in the formulation of tailored therapeutic strategies that address both the present symptoms and the potential future risks.

Keywords: arrhythmogenic cardiomyopathy; electrocardiography; prognosis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study flow.
Figure 2
Figure 2
Graphical abstract summarizing ECG signs with prognostic value in ACM.
Figure 3
Figure 3
ECG signs with increasing prognostic value in ACM.
Figure 4
Figure 4
An ECG of a 42-year-old man summarizing ACM prognostic signs.
See this image and copyright information in PMC

References

    1. Marcus F.I., McKenna W.J., Sherrill D., Basso C., Bauce B., Bluemke D.A., Calkins H., Corrado D., Cox M.G., Daubert J.P., et al. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: Proposed modification of the Task Force Criteria. Eur. Heart J. 2010;31:806–814. doi: 10.1093/eurheartj/ehq025. - DOI - PMC - PubMed
    1. Liberati A., Altman D.G., Tetzlaff J., Mulrrow C., Gotzsche P.C., Ioannidis J.P.A., Clarke M., Devereaux P.J., Kleeijnen J., Moher D., et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ. 2009;339:b2700. doi: 10.1136/bmj.b2700. - DOI - PMC - PubMed
    1. Slim K., Nini E., Forestier D., Kwiatkowski F., Panis Y., Chipponi J. Methodological index for non-randomized studies (minors): Development and validation of a new instrument. ANZ J. Surg. 2003;73:712–716. doi: 10.1046/j.1445-2197.2003.02748.x. - DOI - PubMed
    1. Zorzi A., Migliore F., Elmaghawry M., Silvano M., Marra M.P., Niero A., Nguyen K., Rigato I., Bauce B., Basso C., et al. Electrocardiographic predictors of electroanatomic scar size in arrhythmogenic right ventricular cardiomyopathy: Implications for arrhythmic risk stratification. J. Cardiovasc Electrophysiol. 2013;24:1321–1327. doi: 10.1111/jce.12246. - DOI - PubMed
    1. Kalantarian S., Åström Aneq M., Svetlichnaya J., Sharma S., Vittinghoff E., Klein L., Scheinman M. Long-Term Electrocardiographic and Echocardiographic Progression of Arrhythmogenic Right Ventricular Cardiomyopathy and Their Correlation With Ventricular Tachyarrhythmias. Circ. Heart Failure. 2021;14:e008121. doi: 10.1161/CIRCHEARTFAILURE.120.008121. - DOI - PubMed

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