Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 28;22(4):154.
doi: 10.3390/md22040154.

Assessment of Silver Nanoparticles Derived from Brown Algae Sargassum vulgare: Insight into Antioxidants, Anticancer, Antibacterial and Hepatoprotective Effect

Ragaa A Hamouda  1   2 , Ebtehail S Aljohani  1
Affiliations

Assessment of Silver Nanoparticles Derived from Brown Algae Sargassum vulgare: Insight into Antioxidants, Anticancer, Antibacterial and Hepatoprotective Effect

Ragaa A Hamouda et al. Mar Drugs. .

Abstract

Algae are used as safe materials to fabricate novel nanoparticles to treat some diseases. Marine brown alga Sargassum vulgare are used to fabricate silver nanoparticles (Sv/Ag-NPs). The characterization of Sv/Ag-NPs was determined by TEM, EDX, Zeta potential, XRD, and UV spectroscopy. The Sv/Ag-NPs were investigated as antioxidant, anticancer, and antibacterial activities against Gram-positive bacteria Bacillus mojavensis PP400982, Staphylococcus caprae PP401704, Staphylococcus capitis PP402689, and Staphylococcus epidermidis PP403851. The activity of the Sv/Ag-NPs was evaluated as hepatoprotective in vitro in comparison with silymarin. The UV-visible spectrum of Sv/Ag-NPs appeared at 442 nm; the size of Sv/Ag-NPs is in range between 6.90 to 16.97 nm, and spherical in shape. Different concentrations of Sv/Ag-NPs possessed antioxidant, anticancer activities against (HepG-2), colon carcinoma (HCT-116), cervical carcinoma (HeLa), and prostate carcinoma (PC-3) with IC50 50.46, 45.84, 78.42, and 100.39 µg/mL, respectively. The Sv/Ag-NPs induced the cell viability of Hep G2 cells and hepatocytes treated with carbon tetrachloride. The Sv/Ag-NPs exhibited antibacterial activities against Staphylococcus caprae PP401704, Staphylococcus capitis PP402689, and Staphylococcus epidermidis PP403851. This study strongly suggests the silver nanoparticles derived from Sargassum vulgare showed potential hepato-protective effect against carbon tetrachloride-induced liver cells, and could be used as anticancer and antibacterial activities.

Keywords: Sargassum vulgare; antibacterial; anticancer; antioxidant; hepato-protective.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
UV–visible spectrums of silver nanoparticle solutions biogenically synthesized by brown alga S. vulgare.
Figure 2
Figure 2
Energy dispersive X-ray spectrophotometry analysis of biogenic Sv/Ag-NPs derived from S. vulgare.
Figure 3
Figure 3
X-ray diffraction analysis of biogenic Sv/Ag-NPs derived from S. vulgare.
Figure 4
Figure 4
FT-IR analysis of biogenic Sv/Ag-NPs derived from S. vulgare.
Figure 5
Figure 5
Transmission electron microscopic (TEM) image of biogenic Sv/Ag-NPs derived from S. vulgare.
Figure 6
Figure 6
Particle size distribution of biogenic Sv/Ag-NPs derived from S. vulgare.
Figure 7
Figure 7
Zeta potential analysis of biogenic Sv/Ag-NPs derived from S. vulgare.
Figure 8
Figure 8
Antioxidant activities of the biogenic Sv/Ag-NPs derived from S. vulgare determine by DPPH. Different letters are significant values.
Figure 9
Figure 9
(a) In vitro cytotoxic activity of the biogenic Sv/Ag-NPs derived from S. vulgare against hepatocellular carcinoma (HepG-2). (b) In vitro cytotoxic activity of the biogenic Sv/Ag-NPs derived from S. vulgare against colon carcinoma (HCT-116). (c) In vitro cytotoxic activity of the biogenic Sv/Ag-NPs derived from S. vulgare against cervical carcinoma (HeLa). (d) In vitro cytotoxic activity of the biogenic Sv/Ag-NPs derived from S. vulgare against prostate carcinoma (PC-3).
Figure 9
Figure 9
(a) In vitro cytotoxic activity of the biogenic Sv/Ag-NPs derived from S. vulgare against hepatocellular carcinoma (HepG-2). (b) In vitro cytotoxic activity of the biogenic Sv/Ag-NPs derived from S. vulgare against colon carcinoma (HCT-116). (c) In vitro cytotoxic activity of the biogenic Sv/Ag-NPs derived from S. vulgare against cervical carcinoma (HeLa). (d) In vitro cytotoxic activity of the biogenic Sv/Ag-NPs derived from S. vulgare against prostate carcinoma (PC-3).
Figure 10
Figure 10
Hepatoprotective activity of biogenic Sv/Ag-NPs derived from S. vulgare in compared with Silymarin.
Figure 11
Figure 11
Impact of biogenic Sv/Ag-NPs derived from S. vulgare verses some Gram-positive bacteria.
Figure 12
Figure 12
Suggested mechanism of the antibacterial actions of biogenic Sv/Ag-NPs derived from S. vulgare.
See this image and copyright information in PMC

References

    1. Lewandowska A., Rudzki G., Lewandowski T., Rudzki S. The problems and needs of patients diagnosed with cancer and their caregivers. Int. J. Environ. Res. Public Health. 2021;18:87. doi: 10.3390/ijerph18010087. - DOI - PMC - PubMed
    1. Asrani S.K., Devarbhavi H., Eaton J., Kamath P.S. Burden of liver diseases in the world. J. Hepatol. 2019;70:151–171. doi: 10.1016/j.jhep.2018.09.014. - DOI - PubMed
    1. Abou Seif H.S. Physiological changes due to hepatotoxicity and the protective role of some medicinal plants. Beni-Suef Univ. J. Basic Appl. Sci. 2016;5:134–146. doi: 10.1016/j.bjbas.2016.03.004. - DOI
    1. Doron S., Gorbach S.L. International Encyclopedia of Public Health. Academic Press; Cambridge, MA, USA: 2008. Bacterial infections: Overview; pp. 273–282. - DOI
    1. Rather M.A., Gupta K., Bardhan P., Borah M., Sarkar A., Eldiehy K.S., Mandal M. Microbial biofilm: A matter of grave concern for human health and food industry. J. Basic Microbiol. 2021;61:380–395. doi: 10.1002/jobm.202000678. - DOI - PubMed