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. 2024 Apr 17;9(4):87.
doi: 10.3390/tropicalmed9040087.

Global, Regional and National Burden of Human Cystic Echinococcosis from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019

Tian Tian  1 , Liyuan Miao  2   3 , Wei Wang  4 , Xiaonong Zhou  1   2   3   5
Affiliations

Global, Regional and National Burden of Human Cystic Echinococcosis from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019

Tian Tian et al. Trop Med Infect Dis. .

Abstract

Background: Cystic echinococcosis (CE) is a neglected tropical parasitic disease that poses huge disease, social and economic burdens worldwide; however, there has been little knowledge on the global morbidity, mortality and disability-adjusted life years (DALYs) of CE until now. This study aimed to collect the most up-to-date data about the global, regional and national disease burden due to CE from 1990 to 2019 and to project trends in the next 10 years.

Methods: We measured the global, regional and national morbidity, mortality and DALYs of CE from 1990 to 2019 based on the Global Burden of Disease Study 2019 (GBD 2019) data, and we examined the correlation between socioeconomic development levels and the disease burden of CE. In addition, the disease burden due to CE was projected from 2020 to 2030.

Results: The age-standardized incidence rate (ASIR) of CE reduced from 2.65/105 [95% UI: (1.87/105 to 3.7/105)] in 1990 to 2.6/105 [95% UI: (1.72/105 to 3.79/105)] in 2019 (EAPC = -0.18%). The number of deaths, DALYs, age-standardized mortality rate (ASMR) and age-standardized DALY rate due to CE all showed a tendency to decline from 1990 to 2019. A higher disease burden of CE was measured in women than in men in 2019. There was a significant difference in the ASMR of CE by region according to the socio-demographic index (SDI), and lower burdens of CE were estimated in high-SDI regions. The global ASIR of CE is projected to decline from 2020 to 2030; however, the ASMR and age-standardized DALY rate are projected to rise.

Conclusions: The global burden of CE remains high, and it is recommended that more health resources are allocated to low-SDI regions, women and the elderly aged 55 to 65 years to reduce the disease burden of CE.

Keywords: age-standardized incidence rate; age-standardized mortality rate; burden of disease; cystic echinococcosis; disability-adjusted life year.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Global and national age-standardized incidences of cystic echinococcosis in 2019.
Figure 2
Figure 2
Global age-standardized incidence, mortality and DALYs of cystic echinococcosis in 2019.
Figure 3
Figure 3
Association between age-standardized mortality for cystic echinococcosis and SDI in 21 GBD regions from 1990 to 2019.
Figure 4
Figure 4
Association between age-standardized mortality of cystic echinococcosis and SDI in 204 countries in 2019.
Figure 5
Figure 5
Trends in global age-standardized incidence, mortality and DALYs of cystic echinococcosis from 1990 to 2019 and projections from 2020 to 2030. Left, men; right, women.
See this image and copyright information in PMC

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