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Review
. 2024 Aug 26;17(16):e202301460.
doi: 10.1002/cssc.202301460. Epub 2024 Apr 26.

Perspective on Lignin Conversion Strategies That Enable Next Generation Biorefineries

Shilva Shrestha  1   2   3 , Shubhasish Goswami  1   2 , Deepanwita Banerjee  1   2 , Valentina Garcia  1   4 , Elizabeth Zhou  1 , Charles N Olmsted  5 , Erica L-W Majumder  5 , Deepak Kumar  6 , Deepika Awasthi  1   2 , Aindrila Mukhopadhyay  1   2 , Steven W Singer  1   2 , John M Gladden  1   4 , Blake A Simmons  1   2 , Hemant Choudhary  1   7
Affiliations
Free article
Review

Perspective on Lignin Conversion Strategies That Enable Next Generation Biorefineries

Shilva Shrestha et al. ChemSusChem. .
Free article

Abstract

The valorization of lignin, a currently underutilized component of lignocellulosic biomass, has attracted attention to promote a stable and circular bioeconomy. Successful approaches including thermochemical, biological, and catalytic lignin depolymerization have been demonstrated, enabling opportunities for lignino-refineries and lignocellulosic biorefineries. Although significant progress in lignin valorization has been made, this review describes unexplored opportunities in chemical and biological routes for lignin depolymerization and thereby contributes to economically and environmentally sustainable lignin-utilizing biorefineries. This review also highlights the integration of chemical and biological lignin depolymerization and identifies research gaps while also recommending future directions for scaling processes to establish a lignino-chemical industry.

Keywords: Lignin valorization; chemical depolymerization; computational biology; extremophiles; microbial consortia.

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