Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus

Avner Reshef¹, Thomas Buttgereit², Stephen D Betschel³, Teresa Caballero⁴, Henriette Farkas⁵, Anete S Grumach⁶, Michihiro Hide⁷, Ankur K Jindal⁸, Hilary Longhurst⁹, Jonathan Peter¹⁰, Marc A Riedl¹¹, Yuxiang Zhi¹², Werner Aberer¹³, Mohamed Abuzakouk¹⁴, Tariq Al Farsi¹⁵, Nashat Al Sukaiti¹⁵, Mona Al-Ahmad¹⁶, Sabine Altrichter¹⁷, Emel Aygören-Pürsün¹⁸, Maria Luisa Baeza¹⁹, Noemi Anna Bara²⁰, Andrea Bauer²¹, Jonathan A Bernstein²², Isabelle Boccon-Gibod²³, Hanna Bonnekoh², Laurence Bouillet²⁴, Zenon Brzoza²⁵, Anette Bygum²⁶, Oscar Calderon²⁷, Regis de Albuquerque Campos²⁸, Freya Helena Campos Romero²⁹, Mauro Cancian³⁰, Herberto Jose Chong-Neto³¹, George Christoff³², Stefan Cimbollek³³, Danny M Cohn³⁴, Timothy Craig³⁵, Inna Danilycheva³⁶, Razvigor Darlenski³⁷, Aurélie Du-Thanh³⁸, Luis Felipe Ensina³⁹, Daria Fomina⁴⁰, Luz Fonacier⁴¹, Atsushi Fukunaga⁴², Asli Gelincik⁴³, Pedro Giavina-Bianchi⁴⁴, Kiran Godse⁴⁵, Mark Gompels⁴⁶, Margarida Goncalo⁴⁷, Maia Gotua⁴⁸, Guillermo Guidos-Fogelbach⁴⁹, Mar Guilarte⁵⁰, Alicja Kasperska-Zajac⁵¹, Constance H Katelaris⁵², Tamar Kinaciyan⁵³, Pavel Kolkhir², Kanokvalai Kulthanan⁵⁴, Marcin Kurowski⁵⁵, Elena Latysheva⁵⁶, Antti Lauerma⁵⁷, David Launay⁵⁸, Ramon Lleonart⁵⁹, William Lumry⁶⁰, Alejandro Malbran⁶¹, Ramzy Mohammed Ali⁶², Iman Nasr⁶³, Sandra Nieto-Martinez⁶⁴, Claudio Parisi⁶⁵, Ruby Pawankar⁶⁶, Macarena Piñero-Saavedra⁶⁷, Todor A Popov⁶⁸, Grzegorz Porebski⁶⁹, Alicia Prieto Garcia⁷⁰, Polina Pyatilova², Michael Rudenko⁷¹, Bulent Enis Sekerel⁷², Faradiba Sarquis Serpa⁷³, Farrukh Sheikh⁷⁴, Frank Siebenhaar², Angèle Soria⁷⁵, Maria Staevska⁷⁶, Petra Staubach⁷⁷, Marcin Stobiecki⁶⁹, Simon Francis Thomsen⁷⁸, Massimo Triggiani⁷⁹, Anna Valerieva⁷⁶, Solange Valle⁸⁰, Nguyen Van Dinh⁸¹, Carolina Elisa Vera Ayala², Anna Zalewska-Janowska⁸², Andrea Zanichelli⁸³, Markus Magerl², Marcus Maurer²

Affiliations

¹ Angioedema Research Center, Barzilai University Medical Center, Ashkelon, Israel. Electronic address: aresh@netvision.net.il.
² Angioedema Center of Reference and Excellence (ACARE), Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine, and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.
³ Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
⁴ Department of Allergy, La Paz University Hospital, Hospital La Paz Institute for Health Research (IdiPAZ-Group 44), Biomedical Research Network on Rare Diseases (CIBERER U754), Madrid, Spain; NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
⁵ Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
⁶ Department of Clinical Immunology, University Center Faculdade de Medicina do ABC, Santo André, Brazil.
⁷ Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
⁸ Department of Pediatrics, Allergy Immunology Unit, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁹ Department of Medicine, University of Auckland and Department of Immunology, Auckland City Hospital, Auckland, New Zealand.
¹⁰ Department of Medicine, Division of Allergy and Clinical Immunology, University of Cape Town, and the Allergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa.
¹¹ Division of Rheumatology, Allergy, and Immunology, University of California San Diego, La Jolla, Calif.
¹² Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹³ Department of Dermatology, Medical University of Graz, Graz, Austria.
¹⁴ Allergy and Immunology, Respiratory Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
¹⁵ Department of Pediatric Allergy and Clinical Immunology, The Royal Hospital, Muscat, Oman.
¹⁶ Microbiology Department, College of Medicine, Kuwait University, Kuwait City, Kuwait.
¹⁷ Klinik für Dermatologie und Venerologie, Kepler Uniklinikum, Linz, Austria.
¹⁸ Department of Pediatrics, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
¹⁹ Allergy Department, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases-U761, Gregorio Marañón Health Research Institute (IiSGM), Gregorio Marañón, Madrid, Spain.
²⁰ Romanian Hereditary Angioedema Expertise Centre, Centrul Clinic Mediquest, Sângeorgiu de Mure, Romania.
²¹ Department of Dermatology, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
²² University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Cincinnati, Ohio.
²³ National Reference Center of Angioedema CREAK, Grenoble, France.
²⁴ National Reference Center of Angioedema CREAK, Grenoble, France; Internal medicine department, Grenoble University Hospital, Grenoble, France.
²⁵ Department of Internal Diseases with Division of Allergology, Institute of Medical Sciences, University of Opole, Opole, Poland.
²⁶ Department of Clinical Genetics, Odense University Hospital, Odense, Denmark; Clinical Institute, University of Southern Denmark, Odense, Denmark.
²⁷ Clínica SANNA el Golf, San Isidro, Lima, Peru.
²⁸ Universidade Federal da Bahia, Brazilian Network of Hereditary Angioedema, Salvador, Brazil.
²⁹ Department of Allergy and Clinical Immunology, Hospital Central Sur Alta Especialidad, Mexico City, Mexico City, Mexico.
³⁰ Departmental Unit of Allergology, University Hospital of Padua, Padua, Italy.
³¹ Serviço de Alergia e Imunologia, Complexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil.
³² Excelsior Medical Centre, Sofia, Bulgaria; Medical University-Sofia, Sofia, Bulgaria.
³³ Hospital Universitario Virgen del Rocío, Seville, Spain.
³⁴ Department of Vascular Medicine, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands.
³⁵ Department of Pediatrics, Pennsylvania State University, Hershey, Pa.
³⁶ NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
³⁷ Department of Dermatovenereology, Trakia University, Stara Zagora, Bulgaria.
³⁸ Département de dermatologie, ACARE, Centre Hospitalier Universitaire de Montpellier Montpellier, France.
³⁹ Federal University of São Paulo, São Paulo, Brazil.
⁴⁰ Moscow City Research and Practical Center of Allergoloy and Immunology, Clinical Hospital No. 52, Moscow Healthcare Department, Moscow, Russia.
⁴¹ New York University-Long Island School of Medicine, Mineola, NY.
⁴² Department of Dermatology, Division of Medicine for Function and Morphology of Sensory Organs, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan.
⁴³ Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
⁴⁴ Division of Clinical lmmunology and Allergy, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
⁴⁵ Dr D. Y. Patil Medical College and Hospital, Navi Mumbai, Maharashtra, India.
⁴⁶ Department of Immunology, ACARE, North Bristol NHS Trust, Bristol, United Kingdom.
⁴⁷ Department of Dermatology, Coimbra Hospital and University Center, and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
⁴⁸ Center of Allergy and Immunology and David Tvildiani Medical University, Tbilisi, Georgia.
⁴⁹ SEPI/ENMH Instituto Politecnico Nacional, Mexico City, Mexico.
⁵⁰ Allergy Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
⁵¹ European Center for Diagnosis and Treatment of Urticaria and Angioedema and Department of Clinical Allergology and Urticaria, Medical University of Silesia in Katowice, Katowice, Poland.
⁵² Western Sydney University and Campbelltown Hospital, Campbelltown, Australia.
⁵³ Department of Dermatology, Medical University of Vienna, Vienna, Austria.
⁵⁴ Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
⁵⁵ Department of Immunology and Allergy, Medical University of Lodz, Lodz, Poland.
⁵⁶ NRC Institute of Immunology FMBA of Russia, Moscow, Russia; Pirogov Russian National Research Medical University, Moscow, Russia.
⁵⁷ Department of Dermatology, Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
⁵⁸ University Lille, Inserm, CHU Lille, Service de Médecine Interne et Immunologie Clinique, Centre de Référence des Angioedemes à Kinine (CREAK), U1286-INFINITE-Institute for Translational Research in Inflammation, Lille, France.
⁵⁹ Allergology Department, Hospital Universitari Bellvitge, IDIBILL Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain.
⁶⁰ AARA Research Center, Dallas, Tex.
⁶¹ Unidad de Alergia, Asma e Inmunología Clínica, Buenos Aires, Argentina.
⁶² Department of Medicine, Allergy and Immunology Division, Hamad Medical Corporation, Doha, Qatar.
⁶³ Immunology and Allergy Department, The Royal Hospital, Muscat, Oman.
⁶⁴ Unidad de Genética de la Nutrición, Instituto Nacional de Pediatría, Mexico City, Mexico.
⁶⁵ Pediatric and Adult Allergy sections of the Italian Hospital of Buenos Aires, Buenos Aires, Argentina.
⁶⁶ Nippon Medical School, Tokyo, Japan.
⁶⁷ Allergy Department, Centro Hospitalar do Algarve, Faro, Portugal.
⁶⁸ University Hospital Sv Ivan Rilski, Sofia, Bulgaria.
⁶⁹ Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland.
⁷⁰ Department of Allergy, Gregorio Marañón Health Research Institute (IiSGM), Gregorio Marañón University Hospital, Madrid, Spain.
⁷¹ The London Allergy and Immunology Centre, London, United Kingdom.
⁷² Pediatric Allergy and Asthma Division, Hacettepe University, Ankara, Turkey.
⁷³ Angioedema and Urticaria Reference Center, Hospital Santa Casa de Misericórdia de Vitória, Vitória, Espirito Santo, Brazil.
⁷⁴ Chughtai Medical Center, Lahore, Pakistan.
⁷⁵ Médecine Sorbonne Université, Service de Dermatologie et Allergologie, hôpital Tenon, Assistance Publique Hôpitaux de Paris, Paris, France.
⁷⁶ Department of Allergology, Medical University of Sofia, Clinic of Allergology, University Hospital "Alexandrovska" Sofia, Bulgaria.
⁷⁷ Department of Dermatology, ACARE, University Medical Center Mainz, Mainz, Germany.
⁷⁸ Department of Dermatovenereology, Bispebjerg Hospital, Copenhagen, Denmark.
⁷⁹ Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.
⁸⁰ Department of Internal Medicine, Immunology Service, Hospital Universitario Clementino Fraga Filho, Rio De Janiero, Brazil.
⁸¹ Department of General Internal Medicine, Respiratory-Allergy and Clinical Immunology Unit, Vinmec Healthcare System, Hanoi, Vietnam.
⁸² Department of Psychodermatology, Medical University of Lodz, Lodz, Poland.
⁸³ Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; Operative Unit of Medicine, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.

PMID: 38670233
DOI: 10.1016/j.jaci.2024.03.024

Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus

Avner Reshef et al. J Allergy Clin Immunol. 2024 Aug.

. 2024 Aug;154(2):398-411.e1.

doi: 10.1016/j.jaci.2024.03.024. Epub 2024 Apr 25.

Authors

Affiliations

¹ Angioedema Research Center, Barzilai University Medical Center, Ashkelon, Israel. Electronic address: aresh@netvision.net.il.
² Angioedema Center of Reference and Excellence (ACARE), Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine, and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.
³ Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
⁴ Department of Allergy, La Paz University Hospital, Hospital La Paz Institute for Health Research (IdiPAZ-Group 44), Biomedical Research Network on Rare Diseases (CIBERER U754), Madrid, Spain; NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
⁵ Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
⁶ Department of Clinical Immunology, University Center Faculdade de Medicina do ABC, Santo André, Brazil.
⁷ Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
⁸ Department of Pediatrics, Allergy Immunology Unit, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁹ Department of Medicine, University of Auckland and Department of Immunology, Auckland City Hospital, Auckland, New Zealand.
¹⁰ Department of Medicine, Division of Allergy and Clinical Immunology, University of Cape Town, and the Allergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa.
¹¹ Division of Rheumatology, Allergy, and Immunology, University of California San Diego, La Jolla, Calif.
¹² Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹³ Department of Dermatology, Medical University of Graz, Graz, Austria.
¹⁴ Allergy and Immunology, Respiratory Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
¹⁵ Department of Pediatric Allergy and Clinical Immunology, The Royal Hospital, Muscat, Oman.
¹⁶ Microbiology Department, College of Medicine, Kuwait University, Kuwait City, Kuwait.
¹⁷ Klinik für Dermatologie und Venerologie, Kepler Uniklinikum, Linz, Austria.
¹⁸ Department of Pediatrics, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
¹⁹ Allergy Department, Hospital General Universitario Gregorio Marañón, Biomedical Research Network on Rare Diseases-U761, Gregorio Marañón Health Research Institute (IiSGM), Gregorio Marañón, Madrid, Spain.
²⁰ Romanian Hereditary Angioedema Expertise Centre, Centrul Clinic Mediquest, Sângeorgiu de Mure, Romania.
²¹ Department of Dermatology, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
²² University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Cincinnati, Ohio.
²³ National Reference Center of Angioedema CREAK, Grenoble, France.
²⁴ National Reference Center of Angioedema CREAK, Grenoble, France; Internal medicine department, Grenoble University Hospital, Grenoble, France.
²⁵ Department of Internal Diseases with Division of Allergology, Institute of Medical Sciences, University of Opole, Opole, Poland.
²⁶ Department of Clinical Genetics, Odense University Hospital, Odense, Denmark; Clinical Institute, University of Southern Denmark, Odense, Denmark.
²⁷ Clínica SANNA el Golf, San Isidro, Lima, Peru.
²⁸ Universidade Federal da Bahia, Brazilian Network of Hereditary Angioedema, Salvador, Brazil.
²⁹ Department of Allergy and Clinical Immunology, Hospital Central Sur Alta Especialidad, Mexico City, Mexico City, Mexico.
³⁰ Departmental Unit of Allergology, University Hospital of Padua, Padua, Italy.
³¹ Serviço de Alergia e Imunologia, Complexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil.
³² Excelsior Medical Centre, Sofia, Bulgaria; Medical University-Sofia, Sofia, Bulgaria.
³³ Hospital Universitario Virgen del Rocío, Seville, Spain.
³⁴ Department of Vascular Medicine, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands.
³⁵ Department of Pediatrics, Pennsylvania State University, Hershey, Pa.
³⁶ NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
³⁷ Department of Dermatovenereology, Trakia University, Stara Zagora, Bulgaria.
³⁸ Département de dermatologie, ACARE, Centre Hospitalier Universitaire de Montpellier Montpellier, France.
³⁹ Federal University of São Paulo, São Paulo, Brazil.
⁴⁰ Moscow City Research and Practical Center of Allergoloy and Immunology, Clinical Hospital No. 52, Moscow Healthcare Department, Moscow, Russia.
⁴¹ New York University-Long Island School of Medicine, Mineola, NY.
⁴² Department of Dermatology, Division of Medicine for Function and Morphology of Sensory Organs, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan.
⁴³ Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
⁴⁴ Division of Clinical lmmunology and Allergy, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
⁴⁵ Dr D. Y. Patil Medical College and Hospital, Navi Mumbai, Maharashtra, India.
⁴⁶ Department of Immunology, ACARE, North Bristol NHS Trust, Bristol, United Kingdom.
⁴⁷ Department of Dermatology, Coimbra Hospital and University Center, and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
⁴⁸ Center of Allergy and Immunology and David Tvildiani Medical University, Tbilisi, Georgia.
⁴⁹ SEPI/ENMH Instituto Politecnico Nacional, Mexico City, Mexico.
⁵⁰ Allergy Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
⁵¹ European Center for Diagnosis and Treatment of Urticaria and Angioedema and Department of Clinical Allergology and Urticaria, Medical University of Silesia in Katowice, Katowice, Poland.
⁵² Western Sydney University and Campbelltown Hospital, Campbelltown, Australia.
⁵³ Department of Dermatology, Medical University of Vienna, Vienna, Austria.
⁵⁴ Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
⁵⁵ Department of Immunology and Allergy, Medical University of Lodz, Lodz, Poland.
⁵⁶ NRC Institute of Immunology FMBA of Russia, Moscow, Russia; Pirogov Russian National Research Medical University, Moscow, Russia.
⁵⁷ Department of Dermatology, Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
⁵⁸ University Lille, Inserm, CHU Lille, Service de Médecine Interne et Immunologie Clinique, Centre de Référence des Angioedemes à Kinine (CREAK), U1286-INFINITE-Institute for Translational Research in Inflammation, Lille, France.
⁵⁹ Allergology Department, Hospital Universitari Bellvitge, IDIBILL Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain.
⁶⁰ AARA Research Center, Dallas, Tex.
⁶¹ Unidad de Alergia, Asma e Inmunología Clínica, Buenos Aires, Argentina.
⁶² Department of Medicine, Allergy and Immunology Division, Hamad Medical Corporation, Doha, Qatar.
⁶³ Immunology and Allergy Department, The Royal Hospital, Muscat, Oman.
⁶⁴ Unidad de Genética de la Nutrición, Instituto Nacional de Pediatría, Mexico City, Mexico.
⁶⁵ Pediatric and Adult Allergy sections of the Italian Hospital of Buenos Aires, Buenos Aires, Argentina.
⁶⁶ Nippon Medical School, Tokyo, Japan.
⁶⁷ Allergy Department, Centro Hospitalar do Algarve, Faro, Portugal.
⁶⁸ University Hospital Sv Ivan Rilski, Sofia, Bulgaria.
⁶⁹ Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland.
⁷⁰ Department of Allergy, Gregorio Marañón Health Research Institute (IiSGM), Gregorio Marañón University Hospital, Madrid, Spain.
⁷¹ The London Allergy and Immunology Centre, London, United Kingdom.
⁷² Pediatric Allergy and Asthma Division, Hacettepe University, Ankara, Turkey.
⁷³ Angioedema and Urticaria Reference Center, Hospital Santa Casa de Misericórdia de Vitória, Vitória, Espirito Santo, Brazil.
⁷⁴ Chughtai Medical Center, Lahore, Pakistan.
⁷⁵ Médecine Sorbonne Université, Service de Dermatologie et Allergologie, hôpital Tenon, Assistance Publique Hôpitaux de Paris, Paris, France.
⁷⁶ Department of Allergology, Medical University of Sofia, Clinic of Allergology, University Hospital "Alexandrovska" Sofia, Bulgaria.
⁷⁷ Department of Dermatology, ACARE, University Medical Center Mainz, Mainz, Germany.
⁷⁸ Department of Dermatovenereology, Bispebjerg Hospital, Copenhagen, Denmark.
⁷⁹ Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.
⁸⁰ Department of Internal Medicine, Immunology Service, Hospital Universitario Clementino Fraga Filho, Rio De Janiero, Brazil.
⁸¹ Department of General Internal Medicine, Respiratory-Allergy and Clinical Immunology Unit, Vinmec Healthcare System, Hanoi, Vietnam.
⁸² Department of Psychodermatology, Medical University of Lodz, Lodz, Poland.
⁸³ Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; Operative Unit of Medicine, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.

PMID: 38670233
DOI: 10.1016/j.jaci.2024.03.024

Abstract

Background: Angioedema (AE) manifests with intermittent, localized, self-limiting swelling of the subcutaneous and/or submucosal tissue. AE is heterogeneous, can be hereditary or acquired, may occur only once or be recurrent, may exhibit wheals or not, and may be due to mast cell mediators, bradykinin, or other mechanisms. Several different taxonomic systems are currently used, making it difficult to compare the results of studies, develop multicenter collaboration, and harmonize AE treatment.

Objective: We developed a consensus on the definition, acronyms, nomenclature, and classification of AE (DANCE).

Methods: The initiative involved 91 experts from 35 countries and was endorsed by 53 scientific and medical societies, and patient organizations. A consensus was reached by online discussion and voting using the Delphi process over a period of 16 months (June 2021 to November 2022).

Results: The DANCE initiative resulted in an international consensus on the definition, classification, and terminology of AE. The new consensus classification features 5 types and endotypes of AE and a harmonized vocabulary of abbreviations/acronyms.

Conclusion: The DANCE classification complements current clinical guidelines and expert consensus recommendations on the diagnostic assessment and treatment of AE. DANCE does not replace current clinical guidelines, and expert consensus algorithms and should not be misconstrued in a way that affects reimbursement of medicines prescribed by physicians using sound clinical judgment. We anticipate that this new AE taxonomy and nomenclature will harmonize and facilitate AE research and clinical studies, thereby improving patient care.

Keywords: Angioedema; acronyms; classification; terminology; types.

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Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus

Affiliations

Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus

Authors

Affiliations

Abstract

MeSH terms

LinkOut - more resources

Full Text Sources

Miscellaneous