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Review
. 2024 Apr 15;12(4):867.
doi: 10.3390/biomedicines12040867.

Potential Aspects of the Use of Cytokines in Atopic Dermatitis

Magdalena Krupka-Olek  1   2 , Andrzej Bożek  1 , David Aebisher  3 , Dorota Bartusik-Aebisher  4 , Grzegorz Cieślar  5 , Aleksandra Kawczyk-Krupka  5
Affiliations
Review

Potential Aspects of the Use of Cytokines in Atopic Dermatitis

Magdalena Krupka-Olek et al. Biomedicines. .

Abstract

Atopic dermatitis (AD) is an abnormal inflammatory response in the skin to food, environmental IgE, or non-IgE allergens. This disease belongs to a group of inflammatory diseases that affect both children and adults. In highly developed countries, AD is diagnosed twice as often in children than in adults, which may possibly be connected to increased urbanization. The immune system's pathomechanisms of AD involve humoral mechanisms with IgE, cellular T lymphocytes, dendritic cells occurring in the dermis, Langerhans cells occurring in the epidermis, and other cells infiltrating the site of inflammation (eosinophils, macrophages, mast cells, neutrophils, and basophils). Cytokines are small proteins that affect the interaction and communication between cells. This review characterizes cytokines and potential aspects of the treatment of atopic dermatitis, as well as new strategies that are currently being developed, including targeting cytokines and their receptors.

Keywords: atopic dermatitis; cytokines; treatment.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Pathways of immunological mediators in AD.
See this image and copyright information in PMC

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