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Review
. 2024 Mar 23;14(4):387.
doi: 10.3390/biom14040387.

Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects

Ting Cui  1   2 , Bo-Yu Li  1   2 , Fei Liu  1   2 , Liang Xiong  1   2   3
Affiliations
Review

Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects

Ting Cui et al. Biomolecules. .

Abstract

Curcumae Rhizoma, a traditional Chinese medicine with a wide range of pharmacological activities, is obtained from the dried rhizomes of Curcuma phaeocaulis VaL., Curcuma kwangsiensis S. G. Lee et C. F. Liang, and Curcuma wenyujin Y. H. Chen et C. Ling. Sesquiterpenoids and curcuminoids are found to be the main constituents of Curcumae Rhizoma. Sesquiterpenoids are composed of three isoprene units and are susceptible to complex transformations, such as cyclization, rearrangement, and oxidation. They are the most structurally diverse class of plant-based natural products with a wide range of biological activities and are widely found in nature. In recent years, scholars have conducted abundant studies on the structures and pharmacological properties of components of Curcumae Rhizoma. This article elucidates the chemical structures, medicinal properties, and biological properties of the sesquiterpenoids (a total of 274 compounds) isolated from Curcumae Rhizoma. We summarized extraction and isolation methods for sesquiterpenoids, established a chemical component library of sesquiterpenoids in Curcumae Rhizoma, and analyzed structural variances among sesquiterpenoids sourced from Curcumae Rhizoma of diverse botanical origins. Furthermore, our investigation reveals a diverse array of sesquiterpenoid types, encompassing guaiane-type, germacrane-type, eudesmane-type, elemane-type, cadinane-type, carane-type, bisabolane-type, humulane-type, and other types, emphasizing the relationship between structural diversity and activity. We hope to provide a valuable reference for further research and exploitation and pave the way for the development of new drugs derived from medicinal plants.

Keywords: Curcumae Rhizoma; chemical constituents; pharmacological activity; sesquiterpenoids.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Guaiane-type sesquiterpenoids of Curcumae Rhizoma.
Figure 2
Figure 2
Germacrane-type sesquiterpenoids of Curcumae Rhizoma.
Figure 3
Figure 3
Eudesmane-type sesquiterpenoids of Curcumae Rhizoma.
Figure 4
Figure 4
Elemane-type sesquiterpenoids of Curcumae Rhizoma.
Figure 5
Figure 5
Cadinane-type sesquiterpenoids of Curcumae Rhizoma.
Figure 6
Figure 6
Other-type sesquiterpenoids of Curcumae Rhizoma.
Figure 7
Figure 7
Distribution of sesquiterpenoids in three plant species.
Figure 8
Figure 8
Distribution of guaiane-type and germacrane-type sesquiterpenoids in three medicinal herbs.
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