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. 2024 Apr 17;14(4):427.
doi: 10.3390/jpm14040427.

Long-Term Outcomes of Patients with Biologically Treated Psoriatic Arthritis and Atopic Dermatitis-A Single-Center Experience

Georgiana Strugariu  1   2 , Cristina Pomîrleanu  1   2 , Mara Russu  1   2 , Alexandra Popescu  1 , Luiza Andreea Petrariu  2 , Eugen Ancuta  3 , Rodica Chirieac  4 , Doinița Temelie-Olinici  5 , Codrina Ancuța  1   2
Affiliations

Long-Term Outcomes of Patients with Biologically Treated Psoriatic Arthritis and Atopic Dermatitis-A Single-Center Experience

Georgiana Strugariu et al. J Pers Med. .

Abstract

(1) Background: Although the association between psoriasis and atopic dermatitis (AD) is reported in the literature, scarce data are known about the efficacy of biologic therapy (including TNF and IL-17 inhibitors) in patients with psoriatic arthritis (PsA) and concomitant AD. (2) Objective: We aimed to explore AD in patients with PsA undergoing biologics for their active disease, focusing on prevalence and clinical and potential therapeutic implications. (3) Material and methods: We performed a retrospective analysis of 64 patients with PsA receiving various biological agents, followed-up in an academic outpatient rheumatology department up to 10 years. (4) Results: Atopic diseases were reported in about one third of cases, with a higher incidence of AD (10 cases; 52.6%) vs. atopic rhinitis (6 cases; 31.6%) and allergic asthma (3 cases; 15.8%). Three morphological patterns of AD were recognized including chronic prurigo (3 cases), a chronic lichen simplex (1 case), and eczemas (6 cases). All PsA with concomitant AD displayed a late onset of skin atopy (in their adult life) and demonstrated a specific profile (younger), from urban settings, equally distributed among genders, and requiring switching to a higher number of biologics to achieve disease control. (5) Conclusion: PsA and AD may coexist, requiring special attention when selecting the optimal biologic agent.

Keywords: IL-17 inhibitors; TNF inhibitors; atopic dermatitis; biologic therapy; psoriasis; psoriatic arthritis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow-chart of patients with PsA enrolled; * diagnosed according to 2006 CASPAR criteria; ** loss of evidence or declined participation in study; *** patients with concomitant allergic asthma and allergic rhinitis.
Figure 2
Figure 2
Patients with and without atopy in our cohort of PsA.
Figure 3
Figure 3
Distribution of atopic disorders in PsA with atopy subgroup; AD, atopic dermatitis; AR, allergic rhinitis; AA, allergic asthma; pts, patients.
Figure 4
Figure 4
Morphologic phenotypes of atopic dermatitis in patients with PsA biologically treated.
Figure 5
Figure 5
Non-responder rate between 2013 and 2023 to more than one iTNF in our study groups.
See this image and copyright information in PMC

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