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. 1985 Nov;28(5):691-2.
doi: 10.1128/AAC.28.5.691.

Cilastatin does not alter superoxide dismutase activity

R A Proctor, J A Textor

Cilastatin does not alter superoxide dismutase activity

R A Proctor et al. Antimicrob Agents Chemother. 1985 Nov.

Abstract

Cilastatin inhibits dehydropeptidase-I, a zinc metaloenzyme that metabolizes imipenem. Because zinc stabilizes the mammalian superoxide dismutase, we postulated that cilastatin would also inhibit the dismutase. Cilastatin concentrations at levels threefold higher than those expected in urine, however, did not inhibit the superoxide dismutase activity.

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