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Review
. 2024 Mar 29;60(4):562.
doi: 10.3390/medicina60040562.

Behçet's Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

Salvatore Lavalle  1 , Sebastiano Caruso  2 , Roberta Foti  3 , Caterina Gagliano  1   4 , Salvatore Cocuzza  2 , Luigi La Via  5 , Federica Maria Parisi  2 , Christian Calvo-Henriquez  6 , Antonino Maniaci  1
Affiliations
Review

Behçet's Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

Salvatore Lavalle et al. Medicina (Kaunas). .

Abstract

Behçet's disease is a systemic inflammatory disorder of unknown etiology. The disease manifests with diverse clinical symptoms, most commonly recurrent oral and genital ulcers, skin lesions, and uveitis, though it can affect multiple organ systems. Diagnosis is primarily clinical due to the lack of a definitive diagnostic test, and management involves a multidisciplinary approach to control inflammation and manage symptoms. Current treatment strategies involve corticosteroids, immunosuppressive agents, and, increasingly, biological therapies. Behçet's disease exhibits a higher prevalence along the Silk Road, suggesting a role of environmental and genetic factors. Despite significant progress in understanding its clinical characteristics and treatment approaches, gaps remain in our understanding of its pathogenesis. Future research is needed to elucidate the disease's pathophysiology and optimize treatment strategies.

Keywords: Behçet’s disease; epidemiology; pathogenesis clinical features; treatment approaches.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow-diagram. Behçet’s diagnosis of clinical symptoms, oral, skin, and genital signs. A multidisciplinary approach is mandatory.
Figure 2
Figure 2
Flow diagram on therapeutic management.
See this image and copyright information in PMC

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