Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr 10;60(4):617.
doi: 10.3390/medicina60040617.

Correlation between Radiological Characteristics, PET-CT and Histological Subtypes of Primary Lung Adenocarcinoma-A 102 Case Series Analysis

Nikola Colic  1 , Ruza Stevic  1   2 , Mihailo Stjepanovic  2   3 , Milan Savić  2   4 , Jelena Jankovic  2   3 , Slobodan Belic  2   3 , Jelena Petrovic  2   5 , Nikola Bogosavljevic  2   6 , Dejan Aleksandric  6 , Katarina Lukic  1 , Marko Kostić  2   4 , Dusan Saponjski  1   2 , Jelena Vasic Madzarevic  4 , Stefan Stojkovic  7 , Maja Ercegovac  2   4 , Zeljko Garabinovic  2   4
Affiliations

Correlation between Radiological Characteristics, PET-CT and Histological Subtypes of Primary Lung Adenocarcinoma-A 102 Case Series Analysis

Nikola Colic et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Lung cancer is the second most common form of cancer in the world for both men and women as well as the most common cause of cancer-related deaths worldwide. The aim of this study is to summarize the radiological characteristics between primary lung adenocarcinoma subtypes and to correlate them with FDG uptake on PET-CT. Materials and Methods: This retrospective study included 102 patients with pathohistologically confirmed lung adenocarcinoma. A PET-CT examination was performed on some of the patients and the values of SUVmax were also correlated with the histological and morphological characteristics of the masses in the lungs. Results: The results of this analysis showed that the mean size of AIS-MIA (adenocarcinoma in situ and minimally invasive adenocarcinoma) cancer was significantly lower than for all other cancer types, while the mean size of the acinar cancer was smaller than in the solid type of cancer. Metastases were significantly more frequent in solid adenocarcinoma than in acinar, lepidic, and AIS-MIA cancer subtypes. The maximum standardized FDG uptake was significantly lower in AIS-MIA than in all other cancer types and in the acinar predominant subtype compared to solid cancer. Papillary predominant adenocarcinoma had higher odds of developing contralateral lymph node involvement compared to other types. Solid adenocarcinoma was associated with higher odds of having metastases and with higher SUVmax. AIS-MIA was associated with lower odds of one unit increase in tumor size and ipsilateral lymph node involvement. Conclusions: The correlation between histopathological and radiological findings is crucial for accurate diagnosis and staging. By integrating both sets of data, clinicians can enhance diagnostic accuracy and determine the optimal treatment plan.

Keywords: computed tomography; diagnostics; minimally invasive adenocarcinoma; positron emission tomography.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Adenocarcinoma in situ (AIS) ground-glass nodule.
Figure 2
Figure 2
Minimally invasive adenocarcinoma (MIA).
Figure 3
Figure 3
Lepidic type of adenocarcinoma.
Figure 4
Figure 4
Spiculation of tumor.
Figure 5
Figure 5
PET CT of solid lung lesion on the right and ground-glass lession in the left lung with different FDG uptake.
See this image and copyright information in PMC

References

    1. Cohen J.G., Reymond E., Jankowski A., Brambilla E., Arbib F., Lantuejoul S., Ferretti G.R. Adénocarcinomes pulmonaires: Corrélations entre TDM et histopathologie. J. Radiol. Diagn. Interv. 2016;97:375–384. doi: 10.1016/j.jradio.2016.08.002. - DOI - PubMed
    1. Lantuejoul S., Rouquette I., Brambilla E., Travis W.D. Nouvelle classification OMS 2015 des adénocarcinomes pulmonaires et prénéoplasies. Ann. Pathol. 2016;36:5–14. doi: 10.1016/j.annpat.2015.11.010. - DOI - PubMed
    1. Travis W.D., Brambilla E., Noguchi M., Nicholson A.G., Geisinger K.R., Yatabe Y., Powell C.A., Beer D.G., Riely G.J., Garg K., et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: International Multidisciplinary Classification of Lung Adenocarcinoma: Executive Summary. Proc. Am. Thorac. Soc. 2011;5:381–385. doi: 10.1513/pats.201107-042ST. - DOI - PubMed
    1. Yanagawa M., Johkoh T., Noguchi M., Morii E., Shintani Y., Okumura M., Hata A., Fujiwara M., Honda O., Tomiyama N. Radiological prediction of tumor invasiveness of lung adenocarcinoma on thin-section CT. Medicine. 2017;96:e6331. doi: 10.1097/MD.0000000000006331. - DOI - PMC - PubMed
    1. Cohen J.G., Reymond E., Jankowski A., Brambilla E., Arbib F., Lantuejoul S., Ferretti G.R. Lung adenocarcinomas: Correlation of computed tomography and pathology findings. Diagn. Interv. Imaging. 2016;97:955–963. doi: 10.1016/j.diii.2016.06.021. - DOI - PubMed

Substances