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Review
. 2024 Apr 15;29(8):1791.
doi: 10.3390/molecules29081791.

Obacunone, a Promising Phytochemical Triterpenoid: Research Progress on Its Pharmacological Activity and Mechanism

Yuyang Zhou  1   2 , Jifeng Gu  3   4 , Jiahui Li  1   5 , Huishan Zhang  1 , Mei Wang  1 , Yuanyuan Li  6 , Tianming Wang  6 , Jiajie Wang  1   7 , Rong Shi  1
Affiliations
Review

Obacunone, a Promising Phytochemical Triterpenoid: Research Progress on Its Pharmacological Activity and Mechanism

Yuyang Zhou et al. Molecules. .

Abstract

Obacunone, a natural triterpenoid, is an active component of the herbs Dictamnus dasycarpus Turcz. and Phellodendron amurense Rupr, and an indicator of the herbs' quality. Owing to its multiple health benefits, several studies have investigated the multi-targeting potential action mechanisms of obacunone. To summarize recent developments on the pharmacological actions of obacunone and focus on the underlying molecular mechanisms and signaling networks, we searched PubMed, Europe PMC, Wiley Online Library, Web of Science, Google Scholar, Wanfang Medical Network, and China National Knowledge Infrastructure for articles published prior to March 2024. Existing research indicates obacunone has great potential to become a promising therapeutic option against tumors, fibrotic diseases, bone and cholesterol metabolism diseases, and infections of pathogenic microorganisms, among others. The paper contributes to providing up-to-date references for further research and clinical applications of obacunone.

Keywords: antiviral activity; limonoid; molecular mechanism; obacunone; pharmacology.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Structure of obacunone.
Figure 2
Figure 2
Mechanisms involved in the interactions between obacunone and NRF2.
Figure 3
Figure 3
The main metabolic process of Obacunone.
Figure 4
Figure 4
Summary of obacunone biological activities.
See this image and copyright information in PMC

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